{"doi":"10.1002/alz.70118","title":"Effects of exercise versus usual care on older adults with amnestic mild cognitive impairment: EXERT versus ADNI","abstract":"INTRODUCTION: EXERT was a multisite randomized controlled trial (RCT) examining the effects of moderate-high intensity aerobic training (AX) versus lower-intensity stretching/balance/range of motion (SBR) on cognitive trajectories in older adults with amnestic mild cognitive impairment (aMCI). METHODS: Preplanned post-hoc analyses were conducted to compare each arm to a propensity-matched usual care (no intervention) group from Alzheimer's Disease Neuroimaging Initiative 1 (ADNI-1) selected for similarity across key characteristics. Differences in 12-month trajectories in the primary endpoint (ADAS-Cog-Exec) and magnetic resonance imaging (MRI) volumes in prespecified brain regions were compared. RESULTS: AX and SBR showed significantly less 12-month cognitive decline than ADNI-1 (AX:n = 109, β = 0.169, 95% confidence interval [CI] 0.011-0.328; SBR:n = 105, β = 0.181, 95% CI 0.007-0.354). There were trends of less prefrontal cortex volume loss for both EXERT groups and less AD signature region volume loss for SBR relative to ADNI-1 over 12 months. DISCUSSION: Moderate-high intensity aerobic or low-intensity flexibility exercise for 12 months in participants with aMCI may provide protection against decline relative to usual care. CLINICAL TRIAL REGISTRATION: The EXERT clinical trial is registered at clinicaltrials.gov (NCT02814526). HIGHLIGHTS: EXERT was a randomized controlled trial in sedentary older adults with aMCI. EXERT arms were propensity-matched to a usual care (no intervention) group (Alzheimer's Disease Neuroimaging Initiative 1 [ADNI-1]). High and low-intensity exercise arms had less 12-mo cognitive decline than ADNI-1. There were trends of less prefrontal cortex volume loss for each arm versus ADNI-1.","journal":"Alzheimer s & Dementia","year":2025,"id":519430,"datarank":0.3354306882374491,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.04354416587915207,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.04354416587915207,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":5,"citers_with_citation_signal":4,"citers_with_endowment":4,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9066,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT02814526"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":815221,"name":"Vahan Aslanyan","orcid":"0000-0003-0610-6933","position":1,"is_corresponding":false},{"id":292324,"name":"Diane M. Jacobs","orcid":"0000-0003-0886-6784","position":2,"is_corresponding":false},{"id":108608,"name":"David P. Salmon","orcid":"0000-0003-4533-4090","position":3,"is_corresponding":false},{"id":871814,"name":"Rosemary Morrison","orcid":null,"position":4,"is_corresponding":false},{"id":1197390,"name":"Jeffrey A. Katula","orcid":"0000-0003-2009-2443","position":5,"is_corresponding":false},{"id":377682,"name":"Shelia Jin","orcid":null,"position":6,"is_corresponding":false},{"id":226053,"name":"Ronald G. Thomas","orcid":"0000-0003-1686-4965","position":7,"is_corresponding":false},{"id":302270,"name":"Andrea Z. LaCroix","orcid":"0000-0002-9532-976X","position":8,"is_corresponding":false},{"id":288641,"name":"Judy Pa","orcid":"0000-0002-5788-9352","position":9,"is_corresponding":false},{"id":211526,"name":"Carl W. Cotman","orcid":null,"position":10,"is_corresponding":false},{"id":58516,"name":"Howard Feldman","orcid":"0000-0002-9258-4538","position":11,"is_corresponding":false},{"id":226594,"name":"Laura D. Baker","orcid":"0000-0002-6217-7384","position":12,"is_corresponding":false},{"id":1388362,"name":"for the ADCS EXERT Study Group","orcid":null,"position":13,"is_corresponding":false},{"id":272433,"name":"Aladdin H. Shadyab","orcid":"0000-0002-9693-0522","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":null,"created_at":"2026-07-19T02:49:18.751199Z","pmid":"40271887","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}