{"doi":"10.1002/alz.70047","title":"Using remote, digital, multi‐day testing to characterize long‐term forgetting in cognitively unimpaired older adults","abstract":"INTRODUCTION: Accelerated long-term forgetting (LTF) might be an early marker of subtle memory changes in older adults at risk for Alzheimer's disease (AD). We leveraged remote, multi-day digital testing to characterize LTF in older adults and investigated its association with initial learning and AD imaging biomarkers. METHODS: One hundred four cognitively unimpaired older adults completed a face-name memory task for seven consecutive days and were asked to recognize face-name pairs 1 week later. LTF was computed as the number of correctly identified stimuli divided by a participant's maximum performance during learning. RESULTS: Better learning was associated with less LTF (β = 0.52, 95% confidence interval [CI]:0.34-0.71, p < 0.001). Accelerated LTF was associated with cortical thinning in AD-signature regions (β = 0.33, 95% CI: 0.13-0.52, p = 0.001), but associations with regional tau were more subtle. DISCUSSION: Remote, multi-day testing may facilitate the assessment of LTF as an early cognitive marker of preclinical AD, but further replication is needed. HIGHLIGHTS: Using digital, remote assessments, we evaluated long-term forgetting in cognitively unimpaired older adults. We found a potential association between long-term forgetting and tau in Alzheimer's disease (AD)-related regions. Assessing long-term forgetting may facilitate early detection of AD-related cognitive decline.","journal":"Alzheimer s & Dementia","year":2025,"id":520784,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6965,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":803966,"name":"Daniel Soberanes","orcid":"0000-0001-9099-7294","position":1,"is_corresponding":false},{"id":899425,"name":"Mark A. Dubbelman","orcid":"0000-0002-5708-4925","position":2,"is_corresponding":false},{"id":52698,"name":"Stephanie Hsieh","orcid":"0000-0002-6929-6810","position":3,"is_corresponding":false},{"id":232961,"name":"Keith A. Johnson","orcid":"0000-0002-5916-6043","position":4,"is_corresponding":false},{"id":263297,"name":"Dorene M. Rentz","orcid":"0000-0002-6318-9213","position":5,"is_corresponding":false},{"id":55000,"name":"Reisa A. Sperling","orcid":"0000-0003-1535-6133","position":6,"is_corresponding":false},{"id":313455,"name":"Gad A. Marshall","orcid":"0000-0002-9096-2355","position":7,"is_corresponding":false},{"id":263296,"name":"Rebecca E. Amariglio","orcid":"0009-0009-5878-8930","position":8,"is_corresponding":false},{"id":313457,"name":"Kathryn V. Papp","orcid":"0000-0003-1687-4370","position":9,"is_corresponding":false},{"id":282463,"name":"Roos J. Jutten","orcid":"0000-0002-3712-4790","position":10,"is_corresponding":false},{"id":1029569,"name":"Cassidy Molinare","orcid":"0009-0007-4969-7661","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-19T02:49:32.958846Z","pmid":"40110656","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}