{"doi":"10.1002/alz.70043","title":"Chronic stress, social support, and Alzheimer's blood‐based biomarkers in the HABS‐HD study","abstract":"INTRODUCTION: High levels of chronic stress and low social support have been associated with worse cognition among older adults, but the underlying mechanisms remain unclear. METHODS: We included 2117 older adults (mean age 65.5 years) enrolled in the Health and Aging Brain Study - Health Disparities (HABS-HD). Linear regression models evaluated the associations between social support or chronic stress and Alzheimer's-related blood-based biomarkers (BBMs), including amyloid beta (Aβ) 42/40 ratio, neurofilament light chain (NfL), phosphorylated tau (p-tau)181, and total tau (t-tau). Interactions between chronic stress or social support and gender or race/ethnicity in relation to BBMs were assessed. RESULTS: Higher chronic stress was associated with higher levels of t-tau. Higher social support was associated with lower levels of NfL. Neither gender nor race/ethnicity modified the associations between chronic stress or social support and BBM levels. DISCUSSION: Chronic stress and social support are associated with BBMs of neurodegeneration. HIGHLIGHTS: Higher chronic stress was associated with higher levels of plasma total tau. Higher social support was associated with lower levels of plasma neurofilament light chain. Neither gender nor race/ethnicity modified the associations between chronic stress or social support and levels of blood-based biomarkers. Chronic stress and social support affect pathways related to neurodegeneration.","journal":"Alzheimer s & Dementia","year":2025,"id":518009,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8711,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":414357,"name":"Leigh Johnson","orcid":"0000-0001-7769-8417","position":1,"is_corresponding":false},{"id":326972,"name":"James Hall","orcid":"0000-0002-8153-1537","position":2,"is_corresponding":false},{"id":676476,"name":"James R. Bateman","orcid":"0000-0002-3646-9148","position":3,"is_corresponding":false},{"id":325844,"name":"Lisa L. Barnes","orcid":"0000-0002-0072-9817","position":4,"is_corresponding":false},{"id":270462,"name":"Sid E. O’Bryant","orcid":"0000-0003-0582-5266","position":5,"is_corresponding":false},{"id":228538,"name":"Michelle M. Mielke","orcid":"0000-0001-7177-1185","position":6,"is_corresponding":false},{"id":955928,"name":"Jillian K. Lee","orcid":"0000-0002-3793-3950","position":0,"is_corresponding":true}],"reference_count":67,"raw_metadata":null,"created_at":"2026-07-19T02:49:04.756302Z","pmid":"40042512","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}