{"doi":"10.1002/alz.70018","title":"Relationships between hypometabolism and both β‐amyloid and tau PET in corticobasal syndrome","abstract":"INTRODUCTION: Alzheimer's disease (AD) pathology causes corticobasal syndrome (CBS) in 21%-50% of patients. Studies have assessed hypometabolism in CBS according to β-amyloid (A) positron emission tomography (PET), but the understanding of the association of both AD-tau (T) and A with hypometabolism is incomplete. METHODS: Thirty-three CBS patients and 45 controls underwent fluorodeoxyglucose (FDG), flortaucipir, and Pittsburgh compound-B PET and were classified as A± and T±. FDG-PET uptake was extracted for 12 regions-of-interest in dominant (most affected) and non-dominant hemispheres and compared across A/T groups. RESULTS: A+T+ patients had greater hypometabolism in temporo-parieto-occipital cortices than A+T- and A-T- groups, with no differences observed between the A+T- and A-T- groups. FDG asymmetry was more accentuated in A+T+ patients. Medial temporal and basal ganglia metabolism were similar across AT groups. DISCUSSION: Amyloid and tau positivity contribute synergistically to hypometabolism and asymmetry in temporo-parieto-occipital cortices in CBS, with AD-like patterns of hypometabolism observed only in A+T+ patients. HIGHLIGHTS: Amyloid (A) and tau PET (T) status can be used to stratify CBS patients. A+T+ CBS patients show more hypometabolism in temporo-parieto-occipital cortices. Medial temporal metabolism (typical AD pattern) is similar across AT groups. Parieto-occipital cortices should be assessed when investigating AT pathology in CBS. Amyloid and tau positivity contribute synergistically to hypometabolism and asymmetry in CBS.","journal":"Alzheimer s & Dementia","year":2025,"id":519252,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8655,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":996265,"name":"Austin W. Goodrich","orcid":"0009-0008-5596-0873","position":1,"is_corresponding":false},{"id":1139923,"name":"Yehkyoung C. Stephens","orcid":"0000-0003-0761-3283","position":2,"is_corresponding":false},{"id":253918,"name":"Jonathan Graff‐Radford","orcid":"0000-0003-2770-0691","position":3,"is_corresponding":false},{"id":383666,"name":"Farwa Ali","orcid":"0000-0001-6060-3995","position":4,"is_corresponding":false},{"id":259156,"name":"Mary M. Machulda","orcid":"0000-0003-4834-5967","position":5,"is_corresponding":false},{"id":264830,"name":"Christopher G. Schwarz","orcid":"0000-0002-1466-8357","position":6,"is_corresponding":false},{"id":226057,"name":"Matthew L. Senjem","orcid":"0000-0001-9308-9275","position":7,"is_corresponding":false},{"id":295799,"name":"Federica Agosta","orcid":"0000-0003-3121-4979","position":8,"is_corresponding":false},{"id":247674,"name":"Massimo Filippi","orcid":"0000-0002-5485-0479","position":9,"is_corresponding":false},{"id":49956,"name":"Clifford R. Jack","orcid":"0000-0001-7916-622X","position":10,"is_corresponding":false},{"id":259159,"name":"Val J. Lowe","orcid":"0000-0002-5612-1667","position":11,"is_corresponding":false},{"id":238177,"name":"Keith A. Josephs","orcid":"0000-0003-2930-8634","position":12,"is_corresponding":false},{"id":271235,"name":"Jennifer L. Whitwell","orcid":"0000-0001-6914-1563","position":13,"is_corresponding":false},{"id":1124375,"name":"Alma Ghirelli","orcid":"0000-0001-8440-1036","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-19T02:49:18.751199Z","pmid":"40108988","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}