{"doi":"10.1002/alz.14570","title":"Accuracy of plasma biomarkers to detect Alzheimer's disease proteinopathy prior to dementia","abstract":"Abstract INTRODUCTION Plasma biomarkers sensitive to Alzheimer's disease (AD) proteinopathy prior to the onset of dementia have significant implications for early detection. METHODS In 304 individuals without dementia, we investigated whether C 2 N Diagnostics’ mass spectrometry (MS)‐based plasma biomarkers (amyloid beta 42/40, %phosphorylated tau [p‐tau]181, and %p‐tau217) and amyloid probability scores (APS, PrecivityAD and APS2, PrecivityAD2) are associated with brain amyloid, brain tau, or preclinical cognitive decline. RESULTS In this cohort study, %p‐tau217 and the APS2 had high discriminative accuracy (area under the curve > 0.93) for identifying elevated brain amyloid and tau and were associated with faster preclinical cognitive decline. Using %p‐tau217 or the APS2 in a theoretical AD trial screening scenario reduced amyloid positron emission tomography imaging costs up to 41% or 45%, respectively. DISCUSSION These findings suggest that C 2 N Diagnostics’ MS‐based plasma biomarkers can detect brain amyloid and tau with high accuracy prior to dementia and could aid in identifying candidates for clinical trials or therapeutic intervention. Highlights C 2 N plasma biomarkers differentiated Alzheimer's disease proteinopathy status prior to dementia. Plasma %phosphorylated tau (p‐tau)217 and the C 2 N Diagnostics PrecivityAD2 (APS2) were concordant with amyloid and tau positron emission tomography status. Plasma %p‐tau217 and the APS2 were associated with preclinical cognitive decline.","journal":"Alzheimer s & Dementia","year":2025,"id":517206,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9484,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":340627,"name":"Lianlian Du","orcid":null,"position":1,"is_corresponding":false},{"id":481605,"name":"Rachel Studer","orcid":"0000-0002-4321-6210","position":2,"is_corresponding":false},{"id":289689,"name":"Erin M. Jonaitis","orcid":"0009-0004-5091-8255","position":3,"is_corresponding":false},{"id":1254558,"name":"Sanjay Asthana","orcid":"0000-0002-3298-6324","position":4,"is_corresponding":false},{"id":270461,"name":"Bradley T. Christian","orcid":"0000-0002-9653-559X","position":5,"is_corresponding":false},{"id":289693,"name":"Nathaniel A. Chin","orcid":"0000-0001-8008-9356","position":6,"is_corresponding":false},{"id":1094857,"name":"Kris Kirmess","orcid":null,"position":7,"is_corresponding":false},{"id":98175,"name":"Matthew R. Meyer","orcid":"0000-0002-4919-6927","position":8,"is_corresponding":false},{"id":621688,"name":"Kevin E. Yarasheski","orcid":"0000-0001-5436-2451","position":9,"is_corresponding":false},{"id":595915,"name":"Tim West","orcid":"0000-0003-3267-8249","position":10,"is_corresponding":false},{"id":621685,"name":"Philip B. Verghese","orcid":"0000-0003-4793-564X","position":11,"is_corresponding":false},{"id":621687,"name":"Joel B. Braunstein","orcid":"0000-0002-1155-0206","position":12,"is_corresponding":false},{"id":289688,"name":"Tobey J. Betthauser","orcid":"0000-0001-8856-1352","position":13,"is_corresponding":false},{"id":289687,"name":"Rebecca L. Koscik","orcid":"0000-0003-0025-744X","position":14,"is_corresponding":false},{"id":230038,"name":"Sterling C. Johnson","orcid":"0000-0002-8501-545X","position":15,"is_corresponding":false},{"id":289692,"name":"Karly Alex Cody","orcid":"0000-0001-5996-2560","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-19T02:48:59.410472Z","pmid":"40108829","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}