{"doi":"10.1002/alz.14404","title":"Response to the Letter, “Circulating small RNAs shed light on dementia risk,” by Anthony S. Zannas","abstract":"Dear Editor, We are truly grateful for the positive and thoughtful feedback on our recent studies exploring microRNAs (miRNAs) as biomarkers for Alzheimer's disease (AD).1 It is encouraging to see our work recognized for its potential contribution to the field of AD research. We fully agree that replication is crucial. Although our findings highlight promising miRNA signatures, validating these results in independent cohorts will be key to solidifying their potential clinical relevance. We are confident that future studies will build upon these insights, further advancing the development of reliable biomarkers for early diagnosis and progression tracking. In addition, we would like to highlight the potential of miRNAs in identifying the different molecular and cellular phases of AD pathogenesis. We also appreciate the remarks on the clinical utility of miRNA measurements. As the field evolves, demonstrating the added value of miRNAs alongside established biomarkers remains a priority. We are optimistic that ongoing and future research will help establish miRNAs as complementary tools for improving diagnostic precision. The notion of miRNA-based therapies is particularly exciting. Although this was not the primary focus of our current studies, we agree that stratified RNA therapies hold immense promise as future therapeutic strategies. In AD research, it will be key to treat the right patient at the right time with the right therapeutic approach. The ability to modify miRNA levels in a targeted manner opens new avenues for addressing the different pathological phases in AD, and we look forward to contributing to this research. In conclusion, we are delighted by the recognition of our work and are eager to continue exploring these important questions as the field progresses. We sincerely appreciate the constructive dialogue and look forward to further advancing this exciting area of research. A. Fisher, K. Nho, A.J. Saykin, and I. Delalle We would like to acknowledge the participants of Alzheimer's Disease Neuroimaging Initiative (ADNI) study and other epidemiologic studies for enabling the research on the mechanisms of AD-associated cognitive decline. This study was supported by National Institutes of Health/National Institute of Aging (NIH/NIA) RF1AG078299 “MicroRNAs as Diagnostic and Prognostic Biomarker of Alzheimer's Disease.” The authors declare no conflicts of interest.","journal":"Alzheimer s & Dementia","year":2025,"id":551362,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.958,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":53300,"name":"Kwangsik Nho","orcid":"0000-0002-7624-3872","position":1,"is_corresponding":false},{"id":27595,"name":"Andrew J. Saykin","orcid":"0000-0002-1376-8532","position":2,"is_corresponding":false},{"id":545728,"name":"Ivana Delalle","orcid":"0000-0002-1873-3064","position":3,"is_corresponding":false},{"id":57417,"name":"André Fischer","orcid":"0000-0001-8546-1161","position":0,"is_corresponding":true}],"reference_count":2,"raw_metadata":null,"created_at":"2026-07-19T02:54:25.065895Z","pmid":"39868847","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}