{"doi":"10.1002/alz.14390","title":"Association between dietary inflammatory index score and incident dementia","abstract":"INTRODUCTION: We evaluated whether higher Dietary Inflammatory Index (DII) scores were associated with increased incidence of all-cause dementia and Alzheimer's disease (AD) dementia over 22.3 years of follow-up in the community-based Framingham Heart Study Offspring cohort. METHODS: One thousand four hundred eighty-seven participants (mean ± standard deviation, age in years 69 ± 6) completed food frequency questionnaires (FFQs) and had incident all-cause dementia and AD surveillance data available. RESULTS: Two hundred forty-six participants developed all-cause dementia (including AD, n = 187) over a median follow-up time of 13.1 years. Higher DII scores, averaged across a maximum of three timepoints, were associated with an increased incidence of all-cause dementia and AD after adjustment for demographic, lifestyle, and clinical covariates (hazard ratio [HR] 1.21, 95% confidence interval [CI] 1.10-1.33, P < 0.001; HR 1.20, 95% CI: 1.07-1.34d, P = 0.001, respectively). DISCUSSION: Higher DII scores were associated with a higher risk of incident all-cause dementia and AD. Although these promising findings need to be replicated and further validated, our results suggest that diets that correlate with low DII scores may prevent late-life dementia. HIGHLIGHTS: Higher Dietary Inflammatory Index (DII) scores were associated with an increased incidence of all-cause dementia. Higher DII scores were associated with an increased incidence of Alzheimer's disease dementia. Diets that correlate with low DII scores may prevent late-life dementia.","journal":"Alzheimer s & Dementia","year":2024,"id":441592,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9003,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1167619,"name":"Hannah Gokingco Mesa","orcid":"0000-0001-8788-8732","position":1,"is_corresponding":false},{"id":545421,"name":"Meghan I. Short","orcid":"0000-0002-7849-0180","position":2,"is_corresponding":false},{"id":638026,"name":"Mitzi M. Gonzales","orcid":"0000-0002-8467-0938","position":3,"is_corresponding":false},{"id":273463,"name":"Hugo J. Aparicio","orcid":"0000-0001-8584-1455","position":4,"is_corresponding":false},{"id":481666,"name":"Joel Salinas","orcid":"0000-0002-3735-0018","position":5,"is_corresponding":false},{"id":267715,"name":"Changzheng Yuan","orcid":"0000-0002-2389-8752","position":6,"is_corresponding":false},{"id":326889,"name":"Paul F. Jacques","orcid":"0000-0001-5567-3147","position":7,"is_corresponding":false},{"id":216030,"name":"Alexa Beiser","orcid":null,"position":8,"is_corresponding":false},{"id":17639,"name":"Sudha Seshadri","orcid":"0000-0001-6135-2622","position":9,"is_corresponding":false},{"id":519461,"name":"Mini E. Jacob","orcid":"0000-0002-6225-6656","position":10,"is_corresponding":false},{"id":276095,"name":"Jayandra J. Himali","orcid":null,"position":11,"is_corresponding":false},{"id":843598,"name":"Debora Melo van Lent","orcid":"0000-0002-7392-9289","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-19T02:01:11.152920Z","pmid":"39641390","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}