{"doi":"10.1002/alz.14326","title":"Latent change‐on‐change between amyloid accumulation and cognitive decline","abstract":"INTRODUCTION: While the influence of cross-sectional β-amyloid (Aβ) on longitudinal changes in cognition is well established, longitudinal change-on-change between Aβ and cognition is less explored. METHODS: C-Pittsburgh Compound-B (PiB) positron emission tomography (PET) and the Preclinical Alzheimer's Cognitive Composite-5 (PACC-5) while adjusting for covariates, including cross-sectional medial temporal lobe (MTL) tau-PET burden. We selected 352 clinically normal older participants with up to 9 years of PiB-PET and PACC-5 data from the Harvard Aging Brain Study (HABS). RESULTS: Aβ accumulation was associated with subsequent cognitive decline beyond the effects of cross-sectional Aβ burden. Within this model including covariates such as age, sex, and apolipoprotein ε4 (APOEε4) status, we found no evidence supporting previously published associations between cross-sectional tau-PET and cognitive intercept/slope. DISCUSSION: Short-term Aβ changes are significantly associated with cognitive decline in clinically normal older adults and may eclipse the effect of cross-sectional Aβ and MTL tau. HIGHLIGHTS: Aβ accumulation is associated with subsequent cognitive decline. High Aβ burden is not the sole metric signaling impending cognitive decline. Contrary to prior work, MTL tau-PET and cognition were not associated in our models. Models of bivariate latent Aβ and cognitive change may eclipse the effects of MTL tau.","journal":"Alzheimer s & Dementia","year":2024,"id":456706,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7704,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":311802,"name":"Brian C. 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Schultz","orcid":"0000-0002-0418-0999","position":14,"is_corresponding":false},{"id":263296,"name":"Rebecca E. Amariglio","orcid":"0009-0009-5878-8930","position":15,"is_corresponding":false},{"id":263294,"name":"Heidi I.L. Jacobs","orcid":"0000-0001-7620-3822","position":16,"is_corresponding":false},{"id":275736,"name":"Julie C. Price","orcid":"0000-0001-7131-4865","position":17,"is_corresponding":false},{"id":232961,"name":"Keith A. Johnson","orcid":"0000-0002-5916-6043","position":18,"is_corresponding":false},{"id":68026,"name":"Dorene M. Rentz","orcid":null,"position":19,"is_corresponding":false},{"id":55000,"name":"Reisa A. Sperling","orcid":"0000-0003-1535-6133","position":20,"is_corresponding":false},{"id":261846,"name":"Rachel F. 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