{"doi":"10.1002/alz.14230","title":"Plasma miRNAs across the Alzheimer's disease continuum: Relationship to central biomarkers","abstract":"INTRODUCTION: MicroRNAs (miRNAs) play important roles in gene expression regulation and Alzheimer's disease (AD) pathogenesis. METHODS: We investigated the association between baseline plasma miRNAs and central AD biomarkers from the Alzheimer's Disease Neuroimaging Initiative (ADNI; N = 803): amyloid, tau, and neurodegeneration (A/T/N). Differentially expressed miRNAs and their targets were identified, followed by pathway enrichment analysis. Machine learning approaches were applied to investigate the role of miRNAs as blood biomarkers. RESULTS: We identified nine, two, and eight miRNAs significantly associated with A/T/N positivity, respectively. We identified 271 genes targeted by amyloid-related miRNAs with estrogen signaling receptor-mediated signaling among the enriched pathways. Additionally, 220 genes targeted by neurodegeneration-related miRNAs showed enrichment in pathways including the insulin growth factor 1 pathway. The classification performance of demographic information for A/T/N positivity was increased up to 9% with the inclusion of miRNAs. DISCUSSION: Plasma miRNAs were associated with central A/T/N biomarkers, highlighting their potential as blood biomarkers. HIGHLIGHTS: We performed association analysis of microRNAs (miRNAs) with amyloid/tau/neurodegeneration (A/T/N) biomarker positivity. We identified dysregulated miRNAs for A/T/N biomarker positivity. We identified Alzheimer's disease biomarker-specific/common pathways related to miRNAs. miRNAs improved the classification for A/T/N positivity by up to 9%. Our study highlights the potential of miRNAs as blood biomarkers.","journal":"Alzheimer s & Dementia","year":2024,"id":423905,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9381,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1220245,"name":"Tamina Park","orcid":null,"position":1,"is_corresponding":false},{"id":1219728,"name":"D. Krüger","orcid":"0000-0003-1950-9547","position":2,"is_corresponding":false},{"id":647709,"name":"Tonatiuh Peña Centeno","orcid":"0000-0002-9329-8912","position":3,"is_corresponding":false},{"id":648797,"name":"Susanne Burkhardt","orcid":null,"position":4,"is_corresponding":false},{"id":1220246,"name":"Anna‐Lena Schütz","orcid":null,"position":5,"is_corresponding":false},{"id":1220247,"name":"Yen‐Ning Huang","orcid":null,"position":6,"is_corresponding":false},{"id":1149143,"name":"Thea Rosewood","orcid":"0000-0001-7025-0222","position":7,"is_corresponding":false},{"id":1219729,"name":"Soumilee Chaudhuri","orcid":"0000-0002-8488-6114","position":8,"is_corresponding":false},{"id":867211,"name":"Minyoung Cho","orcid":"0009-0000-9505-0710","position":9,"is_corresponding":false},{"id":53156,"name":"Shannon L. Risacher","orcid":"0000-0002-3304-7943","position":10,"is_corresponding":false},{"id":1032181,"name":"Yang Wan","orcid":"0009-0003-8542-0900","position":11,"is_corresponding":false},{"id":27605,"name":"Leslie M. Shaw","orcid":"0000-0002-7650-1210","position":12,"is_corresponding":false},{"id":647723,"name":"Farahnaz Sananbenesi","orcid":"0000-0002-2123-7694","position":13,"is_corresponding":false},{"id":783800,"name":"Alexander S. Brodsky","orcid":"0000-0001-7357-5153","position":14,"is_corresponding":false},{"id":24806,"name":"Honghuang Lin","orcid":"0000-0003-3043-3942","position":15,"is_corresponding":false},{"id":1220248,"name":"Andre Krunic","orcid":null,"position":16,"is_corresponding":false},{"id":545727,"name":"Jan Krzysztof Blusztajn","orcid":"0000-0001-8438-3122","position":17,"is_corresponding":false},{"id":27595,"name":"Andrew J. Saykin","orcid":"0000-0002-1376-8532","position":18,"is_corresponding":false},{"id":545728,"name":"Ivana Delalle","orcid":"0000-0002-1873-3064","position":19,"is_corresponding":false},{"id":57417,"name":"André Fischer","orcid":"0000-0001-8546-1161","position":20,"is_corresponding":false},{"id":53300,"name":"Kwangsik Nho","orcid":"0000-0002-7624-3872","position":21,"is_corresponding":false},{"id":300139,"name":"for the Alzheimer's Disease Neuroimaging Initiative","orcid":null,"position":22,"is_corresponding":false},{"id":1147730,"name":"Shiwei Liu","orcid":"0000-0003-4711-5959","position":0,"is_corresponding":true}],"reference_count":78,"raw_metadata":null,"created_at":"2026-07-19T01:58:01.889748Z","pmid":"39291737","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}