{"doi":"10.1002/alz.14100","title":"Longitudinal plasma phosphorylated‐tau217 and other related biomarkers in a non‐demented Alzheimer's risk‐enhanced sample","abstract":"INTRODUCTION: Understanding longitudinal change in key plasma biomarkers will aid in detecting presymptomatic Alzheimer's disease (AD). METHODS: Serial plasma samples from 424 Wisconsin Registry for Alzheimer's Prevention participants were analyzed for phosphorylated-tau217 (p-tau217; ALZpath) and other AD biomarkers, to study longitudinal trajectories in relation to disease, health factors, and cognitive decline. Of the participants, 18.6% with known amyloid status were amyloid positive (A+); 97.2% were cognitively unimpaired (CU). RESULTS: In the CU, amyloid-negative (A-) subset, plasma p-tau217 levels increased modestly with age but were unaffected by body mass index and kidney function. In the whole sample, average p-tau217 change rates were higher in those who were A+ (e.g., simple slopes(se) for A+ and A- at age 60 were 0.232(0.028) and 0.038(0.013))). High baseline p-tau217 levels predicted faster preclinical cognitive decline. DISCUSSION: p-tau217 stands out among markers for its strong association with disease and cognitive decline, indicating its potential for early AD detection and monitoring progression. HIGHLIGHTS: Phosphorylated-tau217 (p-tau217) trajectories were significantly different in people who were known to be amyloid positive. Subtle age-related trajectories were seen for all the plasma markers in amyloid-negative cognitively unimpaired. Kidney function and body mass index were not associated with plasma p-tau217 trajectories. Higher plasma p-tau217 was associated with faster preclinical cognitive decline.","journal":"Alzheimer s & Dementia","year":2024,"id":419143,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":43,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5623,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1160541,"name":"Rebecca E. Langhough","orcid":null,"position":1,"is_corresponding":false},{"id":1208434,"name":"Rachael E. Wilson","orcid":"0000-0003-4197-7777","position":2,"is_corresponding":false},{"id":1208435,"name":"Ramiro Eduardo Rea Reyes","orcid":"0000-0001-9749-282X","position":3,"is_corresponding":false},{"id":289691,"name":"Bruce P. Hermann","orcid":"0000-0003-0133-4427","position":4,"is_corresponding":false},{"id":289689,"name":"Erin M. Jonaitis","orcid":"0009-0004-5091-8255","position":5,"is_corresponding":false},{"id":289688,"name":"Tobey J. Betthauser","orcid":"0000-0001-8856-1352","position":6,"is_corresponding":false},{"id":289693,"name":"Nathaniel A. Chin","orcid":"0000-0001-8008-9356","position":7,"is_corresponding":false},{"id":270461,"name":"Bradley T. Christian","orcid":"0000-0002-9653-559X","position":8,"is_corresponding":false},{"id":492419,"name":"Lauren Chaby","orcid":"0000-0003-3352-6060","position":9,"is_corresponding":false},{"id":201260,"name":"Andreas Jeromin","orcid":null,"position":10,"is_corresponding":false},{"id":839574,"name":"Guglielmo Di Molfetta","orcid":"0009-0001-5339-933X","position":11,"is_corresponding":false},{"id":805697,"name":"Wagner S. Brum","orcid":"0000-0002-9777-0559","position":12,"is_corresponding":false},{"id":1038452,"name":"Burak Arslan","orcid":"0000-0001-7229-3226","position":13,"is_corresponding":false},{"id":241104,"name":"Nicholas J. Ashton","orcid":"0000-0002-3579-8804","position":14,"is_corresponding":false},{"id":27600,"name":"Kaj Blennow","orcid":"0000-0002-1890-4193","position":15,"is_corresponding":false},{"id":27601,"name":"Henrik Zetterberg","orcid":"0000-0003-3930-4354","position":16,"is_corresponding":false},{"id":230038,"name":"Sterling C. Johnson","orcid":"0000-0002-8501-545X","position":17,"is_corresponding":false},{"id":340627,"name":"Lianlian Du","orcid":null,"position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":null,"created_at":"2026-07-19T01:57:14.586331Z","pmid":"38970274","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}