{"doi":"10.1002/alz.14048","title":"Heterogeneous treatment effects of sodium‐glucose cotransporter 2 inhibitors on risk of dementia in people with type 2 diabetes: A population‐based cohort study","abstract":"INTRODUCTION: Sodium-glucose cotransporter 2 (SGLT2) inhibitors exhibit potential benefits in reducing dementia risk, yet the optimal beneficiary subgroups remain uncertain. METHODS: Individuals with type 2 diabetes (T2D) initiating either SGLT2 inhibitor or sulfonylurea were identified from OneFlorida+ Clinical Research Network (2016-2022). A doubly robust learning was deployed to estimate risk difference (RD) and 95% confidence interval (CI) of all-cause dementia. RESULTS: Among 35,458 individuals with T2D, 1.8% in the SGLT2 inhibitor group and 4.7% in the sulfonylurea group developed all-cause dementia over a 3.2-year follow-up, yielding a lower risk for SGLT2 inhibitors (RD, -2.5%; 95% CI, -3.0% to -2.1%). Hispanic ethnicity and chronic kidney disease were identified as the two important variables to define four subgroups in which RD ranged from -4.3% (-5.5 to -3.2) to -0.9% (-1.9 to 0.2). DISCUSSION: Compared to sulfonylureas, SGLT2 inhibitors were associated with a reduced risk of all-cause dementia, but the association varied among different subgroups. HIGHLIGHTS: New users of sodium-glucose cotransporter 2 (SGLT2) inhibitors were significantly associated with a lower risk of all-cause dementia as compared to those of sulfonylureas. The association varied among different subgroups defined by Hispanic ethnicity and chronic kidney disease. A significantly lower risk of Alzheimer's disease and vascular dementia was observed among new users of SGLT2 inhibitors compared to those of sulfonylureas.","journal":"Alzheimer s & Dementia","year":2024,"id":424236,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.861,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":404842,"name":"William T. Donahoo","orcid":"0000-0002-2126-860X","position":1,"is_corresponding":false},{"id":1017895,"name":"Mikael Svensson","orcid":"0000-0003-1179-7003","position":2,"is_corresponding":false},{"id":703888,"name":"C. Elizabeth Shaaban","orcid":"0000-0002-3016-1951","position":3,"is_corresponding":false},{"id":767026,"name":"Glenn E. Smith","orcid":"0000-0003-1506-9484","position":4,"is_corresponding":false},{"id":1069167,"name":"Michael S. Jaffee","orcid":null,"position":5,"is_corresponding":false},{"id":1170725,"name":"Yu Huang","orcid":"0000-0001-7373-4716","position":6,"is_corresponding":false},{"id":368454,"name":"Xia Hu","orcid":"0000-0003-2234-3226","position":7,"is_corresponding":false},{"id":50832,"name":"Ying Lü","orcid":"0000-0002-7698-8962","position":8,"is_corresponding":false},{"id":276926,"name":"Ramzi G. Salloum","orcid":"0000-0002-8139-2418","position":9,"is_corresponding":false},{"id":70543,"name":"Steven T. DeKosky","orcid":"0000-0003-3743-2758","position":10,"is_corresponding":false},{"id":23318,"name":"Jiang Bian","orcid":"0000-0002-2238-5429","position":11,"is_corresponding":false},{"id":415391,"name":"Jingchuan Guo","orcid":"0000-0001-9799-2592","position":12,"is_corresponding":false},{"id":545934,"name":"Huilin Tang","orcid":"0000-0002-5814-6657","position":0,"is_corresponding":true}],"reference_count":74,"raw_metadata":null,"created_at":"2026-07-19T01:58:07.191194Z","pmid":"38958394","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}