{"doi":"10.1002/alz.13887","title":"Effect of vigorous‐intensity physical activity on incident cognitive impairment in high‐risk hypertension","abstract":"INTRODUCTION: We investigated the effect vigorous physical activity (VPA) on the risk of incident mild cognitive impairment (MCI) and probable dementia among individuals with high-risk hypertension. METHODS: Baseline self-reported frequency of VPA was categorized into low VPA (<1 session/week), and high VPA (≥1 session/week). We used multivariate Cox regression analysis to examine the association of VPA categories with incident MCI and probable dementia events. RESULTS: Participants in the high VPA category, compared with low VPA, experienced lower events rates (per 1000 person-years) of MCI (13.9 vs 19.7), probable dementia (6.3 vs 9.0), and MCI/probable dementia (18.5 vs 25.8). In the multivariate Cox regression model, high VPA, compared with low VPA, was associated with lower risk of MCI, probable dementia, and MCI/probable dementia (HR [95% CI]: 0.81 [0.68-0.97], 0.80 [0.63-1.03], and 0.82 [0.70-0.96]), respectively. DISCUSSION: This study provides evidence that VPA may preserve cognitive function in high-risk patients with hypertension. HIGHLIGHTS: Hypertension is associated with an increased risk of cognitive impairment Physical activity (PA) is associated with a lower risk of decline in cognition The effect of ≥1 sessions of vigorous-intensity PA (VPA) per week was assessed This analysis included SPRINT MIND trial participants with high-risk hypertension ≥1 VPA sessions/week was associated with lower risk of future cognitive impairment.","journal":"Alzheimer s & Dementia","year":2024,"id":435358,"datarank":0.44707353177634296,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.062331128157112406,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.062331128157112406,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":11,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9602,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT01206062"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":958864,"name":"Christopher L. Schaich","orcid":"0000-0002-5302-0828","position":1,"is_corresponding":false},{"id":1242952,"name":"Ahmad Imtiaz Muhammad","orcid":null,"position":2,"is_corresponding":false},{"id":1242508,"name":"Isabella Epiu","orcid":"0000-0001-9003-3188","position":3,"is_corresponding":false},{"id":1122931,"name":"Juliana H. Namutebi","orcid":null,"position":4,"is_corresponding":false},{"id":430016,"name":"Parag Anilkumar Chevli","orcid":"0000-0002-4084-8175","position":5,"is_corresponding":false},{"id":1122508,"name":"Joseph Kazibwe","orcid":"0000-0002-8315-1503","position":6,"is_corresponding":false},{"id":325846,"name":"Timothy M. Hughes","orcid":"0000-0002-2919-7199","position":7,"is_corresponding":false},{"id":865708,"name":"Rishi Rikhi","orcid":"0000-0002-8013-4564","position":8,"is_corresponding":false},{"id":159550,"name":"Michael D Shapiro","orcid":"0000-0002-9071-3287","position":9,"is_corresponding":false},{"id":706211,"name":"Joseph Yeboah","orcid":"0000-0001-6274-5882","position":10,"is_corresponding":false},{"id":1122507,"name":"Richard Kazibwe","orcid":"0000-0001-7085-3373","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-19T02:00:03.406367Z","pmid":"38842100","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}