{"doi":"10.1002/alz.13853","title":"Antidepressant exposure and long‐term dementia risk in a nationwide retrospective study on US veterans with midlife major depressive disorder","abstract":"INTRODUCTION: The use of antidepressants in major depressive disorder (MDD) has been reported to influence long-term risk of Alzheimer's disease (AD) and AD-related dementias (AD/ADRD), but studies are conflicting. METHODS: We used inverse probability weighted (IPW) Cox models with time-varying covariates in a retrospective cohort study among midlife veterans with MDD within the US Veterans Affairs healthcare system from January 1, 2000 to June 1, 2022. RESULTS: A total of 35,200 patients with MDD were identified. No associations were seen regarding the effect of being exposed to any antidepressant versus no exposure on AD/ADRD risk (events = 1,056, hazard ratio = 0.94, 95% confidence interval: 0.81 to 1.09) or the exposure to specific antidepressant classes versus no exposure. A risk reduction was observed for female patients in a stratified analysis; however, the number of cases was small. DISCUSSION: Our study suggests that antidepressant exposure has no effect on AD/ADRD risk. The association in female patients should be interpreted with caution and requires further attention. HIGHLIGHTS: We studied whether antidepressant use was associated with future dementia risk. We specifically focused on patients after their first-ever diagnosis of depression. We used IPW Cox models with time-varying covariates and a large observation window. Our study did not identify an effect of antidepressant use on dementia risk. A risk reduction was observed in female patients, but the number of cases was small.","journal":"Alzheimer s & Dementia","year":2024,"id":435232,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9525,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":294293,"name":"June K. Corrigan","orcid":"0000-0002-7514-0177","position":1,"is_corresponding":false},{"id":56396,"name":"Chunlei Zheng","orcid":"0000-0002-9737-461X","position":2,"is_corresponding":false},{"id":707545,"name":"Kaitlin N. Swinnerton","orcid":"0000-0002-7429-9960","position":3,"is_corresponding":false},{"id":578313,"name":"Sean Jacobson","orcid":"0000-0001-9937-419X","position":4,"is_corresponding":false},{"id":280990,"name":"Jennifer La","orcid":"0000-0003-2266-0221","position":5,"is_corresponding":false},{"id":125643,"name":"Rebecca A. Betensky","orcid":"0000-0002-3793-1437","position":6,"is_corresponding":false},{"id":232608,"name":"Ricardo S. Osorio","orcid":"0000-0002-2735-9609","position":7,"is_corresponding":false},{"id":1242870,"name":"Sharon Madanes","orcid":null,"position":8,"is_corresponding":false},{"id":915091,"name":"Nunzio Pomara","orcid":"0000-0003-2204-0102","position":9,"is_corresponding":false},{"id":500858,"name":"Dan V. Iosifescu","orcid":"0000-0002-2512-2835","position":10,"is_corresponding":false},{"id":11348,"name":"Mary T. Brophy","orcid":"0000-0003-2314-4368","position":11,"is_corresponding":false},{"id":56409,"name":"Nhan V. Do","orcid":"0000-0001-6868-7011","position":12,"is_corresponding":false},{"id":56417,"name":"Nathanael R. Fillmore","orcid":"0000-0002-8058-3423","position":13,"is_corresponding":false},{"id":663274,"name":"Jaime Ramos‐Cejudo","orcid":"0000-0002-0993-9909","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-19T02:00:03.406367Z","pmid":"38717046","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}