{"doi":"10.1002/alz.13852","title":"Premenopausal bilateral oophorectomy and brain white matter brain integrity in later‐life","abstract":"INTRODUCTION: Premenopausal bilateral oophorectomy (PBO) is associated with later-life cognition, but the underlying brain changes remain unclear. We assessed the impact of PBO and PBO age on white matter integrity. METHODS: Female participants with regional diffusion tensor imaging (DTI) metrics of fractional anisotropy (FA) and mean diffusivity (MD) were included (22 with PBO < 40 years; 43 with PBO 40-45 years; 39 with PBO 46-49 years; 907 referents without PBO < 50 years). Linear regression models adjusted for age and apolipoprotein E (APOE) genotype. RESULTS: Females with PBO < 40 years, compared to referents, had lower FA and higher MD in the anterior corona radiata, genu of the corpus collosum, inferior fronto-occipital fasciculus, superior occipital, and superior temporal white matter. Females who underwent PBO between 45 and 49 also had some changes in white matter integrity. DISCUSSION: Females who underwent PBO < 40 years had reduced white matter integrity across multiple regions in later-life. These results are important for females considering PBO for noncancerous conditions. HIGHLIGHTS: Females with premenopausal bilateral oophorectomy (PBO) < 40 years had lower FA versus referents. Females with PBO < 40 years had higher MD in many regions versus referents. Adjusting for estrogen replacement therapy use did not attenuate results. Females with PBO 45-49 years also had some white matter changes versus referents.","journal":"Alzheimer s & Dementia","year":2024,"id":457862,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8559,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":292107,"name":"Ryan D. Frank","orcid":"0000-0002-5561-0637","position":1,"is_corresponding":false},{"id":1074308,"name":"Luke R. Christenson","orcid":null,"position":2,"is_corresponding":false},{"id":318670,"name":"Robert I. Reid","orcid":"0000-0003-2391-8650","position":3,"is_corresponding":false},{"id":253904,"name":"Julie A. Fields","orcid":"0000-0002-1282-9866","position":4,"is_corresponding":false},{"id":1283821,"name":"Zhenya E. Knyazhanskaya","orcid":null,"position":5,"is_corresponding":false},{"id":489088,"name":"Firat Kara","orcid":"0000-0003-4679-8110","position":6,"is_corresponding":false},{"id":226058,"name":"Prashanthi Vemuri","orcid":"0000-0003-4286-0589","position":7,"is_corresponding":false},{"id":17537,"name":"Walter A. Rocca","orcid":"0000-0002-1832-7664","position":8,"is_corresponding":false},{"id":108589,"name":"Kejal Kantarci","orcid":"0000-0002-8001-2081","position":9,"is_corresponding":false},{"id":228538,"name":"Michelle M. Mielke","orcid":"0000-0001-7177-1185","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-19T02:03:41.744499Z","pmid":"38899634","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}