{"doi":"10.1002/alz.13659","title":"Parenchymal CSF fraction is a measure of brain glymphatic clearance and positively associated with amyloid beta deposition on PET","abstract":"INTRODUCTION: Mapping of microscopic changes in the perivascular space (PVS) of the cerebral cortex, beyond magnetic resonance-visible PVS in white matter, may enhance our ability to diagnose Alzheimer's disease (AD) early. METHODS: C Pittsburgh compound B positron emission tomography to investigate their relationship at both the subject and voxel levels. RESULTS: Our research has demonstrated a positive correlation between the parenchymal CSFF, a non-invasive imaging biomarker indicative of parenchymal glymphatic clearance, and Aβ deposition, observed at both individual and voxel-based assessments in the posterior cingulate cortex. DISCUSSION: This study shows that an increased parenchymal CSFF is associated with Aβ deposition, suggesting that CSFF could serve as a biomarker for brain glymphatic clearance, which can be used to detect early fluid changes in PVS predisposing individuals to the development of AD. HIGHLIGHTS: Cerebrospinal fluid fraction (CSFF) could be a biomarker of parenchymal perivascular space. CSFF is positively associated with amyloid beta (Aβ) deposition at subject level. CSFF in an Aβ+ region is higher than in an Aβ- region in the posterior cingulate cortex. Correspondence is found between Aβ deposition and glymphatic clearance deficits measured by CSFF.","journal":"Alzheimer s & Dementia","year":2024,"id":422412,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8834,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":314691,"name":"Thanh D. Nguyen","orcid":"0000-0002-1411-7694","position":1,"is_corresponding":false},{"id":917565,"name":"Gloria Chiang","orcid":"0000-0001-9925-0816","position":2,"is_corresponding":false},{"id":1067242,"name":"Xiuyuan H. Wang","orcid":null,"position":3,"is_corresponding":false},{"id":1039130,"name":"Ke Xi","orcid":"0000-0002-2213-3459","position":4,"is_corresponding":false},{"id":1216734,"name":"Tsung‐Wei Hu","orcid":null,"position":5,"is_corresponding":false},{"id":777046,"name":"Emily Tanzi","orcid":"0000-0002-3633-0680","position":6,"is_corresponding":false},{"id":746902,"name":"Tracy Butler","orcid":"0000-0003-0130-8122","position":7,"is_corresponding":false},{"id":259106,"name":"Mony J. de Leon","orcid":"0000-0003-2245-4380","position":8,"is_corresponding":false},{"id":263826,"name":"Yi Li","orcid":"0000-0002-3875-3513","position":9,"is_corresponding":false},{"id":725495,"name":"Liangdong Zhou","orcid":"0000-0002-8389-274X","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-19T01:57:46.393290Z","pmid":"38184796","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}