{"doi":"10.1002/alz.13559","title":"Tau‐neurodegeneration <i>mismatch</i> reveals vulnerability and resilience to comorbidities in Alzheimer's continuum","abstract":"INTRODUCTION: Variability in relationship of tau-based neurofibrillary tangles (T) and neurodegeneration (N) in Alzheimer's disease (AD) arises from non-specific nature of N, modulated by non-AD co-pathologies, age-related changes, and resilience factors. METHODS: We used regional T-N residual patterns to partition 184 patients within the Alzheimer's continuum into data-driven groups. These were compared with groups from 159 non-AD (amyloid \"negative\") patients partitioned using cortical thickness, and groups in 98 patients with ante mortem MRI and post mortem tissue for measuring N and T, respectively. We applied the initial T-N residual model to classify 71 patients in an independent cohort into predefined groups. RESULTS: AD groups displayed spatial T-N mismatch patterns resembling neurodegeneration patterns in non-AD groups, similarly associated with non-AD factors and diverging cognitive outcomes. In the autopsy cohort, limbic T-N mismatch correlated with TDP-43 co-pathology. DISCUSSION: T-N mismatch may provide a personalized approach for determining non-AD factors associated with resilience/vulnerability in AD.","journal":"Alzheimer s & Dementia","year":2023,"id":333538,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8025,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":259730,"name":"Michael Tran Duong","orcid":"0000-0003-0312-5530","position":1,"is_corresponding":false},{"id":259728,"name":"Long Xie","orcid":"0000-0002-7184-7028","position":2,"is_corresponding":false},{"id":260102,"name":"Robin de Florès","orcid":"0000-0003-3953-3392","position":3,"is_corresponding":false},{"id":245770,"name":"Hayley Richardson","orcid":"0009-0007-4898-7536","position":4,"is_corresponding":false},{"id":306961,"name":"Gyujoon Hwang","orcid":"0000-0002-9497-2999","position":5,"is_corresponding":false},{"id":260099,"name":"Laura E.M. Wisse","orcid":"0000-0001-7504-3943","position":6,"is_corresponding":false},{"id":681234,"name":"Michael DiCalogero","orcid":null,"position":7,"is_corresponding":false},{"id":227422,"name":"Corey T. McMillan","orcid":"0000-0002-7581-6405","position":8,"is_corresponding":false},{"id":227427,"name":"John Robinson","orcid":"0000-0001-6858-2367","position":9,"is_corresponding":false},{"id":227428,"name":"Sharon X. Xie","orcid":"0000-0002-7886-4103","position":10,"is_corresponding":false},{"id":107087,"name":"Edward B. Lee","orcid":"0000-0002-4589-1180","position":11,"is_corresponding":false},{"id":227417,"name":"David J. Irwin","orcid":"0000-0002-5599-5098","position":12,"is_corresponding":false},{"id":19606,"name":"Bradford C. Dickerson","orcid":"0000-0002-5958-3445","position":13,"is_corresponding":false},{"id":34918,"name":"Christos Davatzikos","orcid":"0000-0002-1025-8561","position":14,"is_corresponding":false},{"id":230030,"name":"Ilya M. Nasrallah","orcid":"0000-0003-2346-7562","position":15,"is_corresponding":false},{"id":259082,"name":"Paul A. Yushkevich","orcid":"0000-0001-8543-4016","position":16,"is_corresponding":false},{"id":230045,"name":"David A. Wolk","orcid":"0000-0002-3554-3481","position":17,"is_corresponding":false},{"id":265855,"name":"Sandhitsu R. Das","orcid":"0000-0003-0530-2887","position":18,"is_corresponding":false},{"id":300139,"name":"for the Alzheimer's Disease Neuroimaging Initiative","orcid":null,"position":19,"is_corresponding":false},{"id":680497,"name":"Xueying Lyu","orcid":"0000-0002-2885-3940","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-19T01:09:39.719497Z","pmid":"38050662","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}