{"doi":"10.1002/alz.13539","title":"Modeling the temporal evolution of plasma p‐tau in relation to amyloid beta and tau PET","abstract":"INTRODUCTION: The timing of plasma biomarker changes is not well understood. The goal of this study was to evaluate the temporal co-evolution of plasma and positron emission tomography (PET) Alzheimer's disease (AD) biomarkers. METHODS: We included 1408 Mayo Clinic Study of Aging and Alzheimer's Disease Research Center participants. An accelerated failure time (AFT) model was fit with amyloid beta (Aβ) PET, tau PET, plasma p-tau217, p-tau181, and glial fibrillary acidic protein (GFAP) as endpoints. RESULTS: Individual timing of plasma p-tau progression was strongly associated with Aβ PET and GFAP progression. In the population, GFAP became abnormal first, then Aβ PET, plasma p-tau, and tau PET temporal meta-regions of interest when applying cut points based on young, cognitively unimpaired participants. DISCUSSION: Plasma p-tau is a stronger indicator of a temporally linked response to elevated brain Aβ than of tau pathology. While Aβ deposition and a rise in GFAP are upstream events associated with tau phosphorylation, the temporal link between p-tau and Aβ PET was the strongest. HIGHLIGHTS: Plasma p-tau progression was more strongly associated with Aβ than tau PET. Progression on plasma p-tau was associated with Aβ PET and GFAP progression. P-tau181 and p-tau217 become abnormal after Aβ PET and before tau PET. GFAP became abnormal first, before plasma p-tau and Aβ PET.","journal":"Alzheimer s & Dementia","year":2023,"id":323797,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":36,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5747,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":318778,"name":"Emily S. Lundt","orcid":"0000-0002-4754-8642","position":1,"is_corresponding":false},{"id":270817,"name":"Terry M. Therneau","orcid":"0000-0003-1490-6711","position":2,"is_corresponding":false},{"id":272791,"name":"Heather J. Wiste","orcid":null,"position":3,"is_corresponding":false},{"id":253918,"name":"Jonathan Graff‐Radford","orcid":"0000-0003-2770-0691","position":4,"is_corresponding":false},{"id":645161,"name":"Alicia Algeciras‐Schimnich","orcid":"0000-0002-4455-6217","position":5,"is_corresponding":false},{"id":259159,"name":"Val J. Lowe","orcid":"0000-0002-5612-1667","position":6,"is_corresponding":false},{"id":228538,"name":"Michelle M. Mielke","orcid":"0000-0001-7177-1185","position":7,"is_corresponding":false},{"id":264830,"name":"Christopher G. Schwarz","orcid":"0000-0002-1466-8357","position":8,"is_corresponding":false},{"id":226057,"name":"Matthew L. Senjem","orcid":"0000-0001-9308-9275","position":9,"is_corresponding":false},{"id":270814,"name":"Jeffrey L. Gunter","orcid":"0000-0001-7813-9078","position":10,"is_corresponding":false},{"id":49955,"name":"David S. Knopman","orcid":"0000-0002-6544-066X","position":11,"is_corresponding":false},{"id":226058,"name":"Prashanthi Vemuri","orcid":"0000-0003-4286-0589","position":12,"is_corresponding":false},{"id":27599,"name":"Ronald C. Petersen","orcid":"0000-0002-8178-6601","position":13,"is_corresponding":false},{"id":49956,"name":"Clifford R. Jack","orcid":"0000-0001-7916-622X","position":14,"is_corresponding":false},{"id":270813,"name":"Petrice M. Cogswell","orcid":"0000-0002-8128-4476","position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":null,"created_at":"2026-07-19T01:08:06.496579Z","pmid":"37963289","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}