{"doi":"10.1002/alz.13525","title":"A novel ultrasensitive assay for plasma p‐tau217: Performance in individuals with subjective cognitive decline and early Alzheimer's disease","abstract":"INTRODUCTION: Detection of Alzheimer's disease (AD) pathophysiology among individuals with mild cognitive changes and those experiencing subjective cognitive decline (SCD) remains challenging. Plasma phosphorylated tau 217 (p-tau217) is one of the most promising of the emerging biomarkers for AD. However, accessible methods are limited. METHODS: We employed a novel p-tau217 immunoassay (University of Gothenburg [UGOT] p-tau217) in four independent cohorts (n = 308) including a cerebrospinal fluid (CSF) biomarker-classified cohort (Discovery), two cohorts consisting mostly of cognitively unimpaired (CU) and mild cognitively impaired (MCI) participants (MYHAT and Pittsburgh), and a population-based cohort of individuals with SCD (Barcelonaβeta Brain Research Center's Alzheimer's At-Risk Cohort [β-AARC]). RESULTS: UGOT p-tau217 showed high accuracy (area under the curve [AUC] = 0.80-0.91) identifying amyloid beta (Aβ) pathology, determined either by Aβ positron emission tomography or CSF Aβ42/40 ratio. In individuals experiencing SCD, UGOT p-tau217 showed high accuracy identifying those with a positive CSF Aβ42/40 ratio (AUC = 0.91). DISCUSSION: UGOT p-tau217 can be an easily accessible and efficient way to screen and monitor patients with suspected AD pathophysiology, even in the early stages of the continuum.","journal":"Alzheimer s & Dementia","year":2023,"id":316798,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":92,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9586,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":805699,"name":"Pâmela C.L. Ferreira","orcid":"0000-0003-2134-9829","position":1,"is_corresponding":false},{"id":839825,"name":"Armand González‐Escalante","orcid":"0000-0001-9456-5405","position":2,"is_corresponding":false},{"id":636000,"name":"Laia Montoliu‐Gaya","orcid":"0000-0001-7684-6318","position":3,"is_corresponding":false},{"id":839824,"name":"Paula Ortiz‐Romero","orcid":"0000-0002-6378-6763","position":4,"is_corresponding":false},{"id":841866,"name":"Przemysław R. Kac","orcid":"0000-0001-5083-0924","position":5,"is_corresponding":false},{"id":843049,"name":"Michael Turton","orcid":null,"position":6,"is_corresponding":false},{"id":270063,"name":"Hlin Kvartsberg","orcid":"0000-0002-4481-508X","position":7,"is_corresponding":false},{"id":241104,"name":"Nicholas J. Ashton","orcid":"0000-0002-3579-8804","position":8,"is_corresponding":false},{"id":27601,"name":"Henrik Zetterberg","orcid":"0000-0003-3930-4354","position":9,"is_corresponding":false},{"id":843050,"name":"Peter Harrison","orcid":null,"position":10,"is_corresponding":false},{"id":805700,"name":"Bruna Bellaver","orcid":"0000-0002-2212-3373","position":11,"is_corresponding":false},{"id":805703,"name":"Guilherme Povala","orcid":"0000-0002-2023-6569","position":12,"is_corresponding":false},{"id":236168,"name":"Victor L. Villemagne","orcid":"0000-0002-5832-9875","position":13,"is_corresponding":false},{"id":272069,"name":"Tharick A. Pascoal","orcid":"0000-0001-9057-8014","position":14,"is_corresponding":false},{"id":251490,"name":"Mary Ganguli","orcid":"0000-0003-2762-7105","position":15,"is_corresponding":false},{"id":1021921,"name":"Anne D. Cohen","orcid":null,"position":16,"is_corresponding":false},{"id":635121,"name":"Carolina Minguillón","orcid":"0000-0002-2782-6908","position":17,"is_corresponding":false},{"id":656935,"name":"José Contador","orcid":"0000-0002-9692-1570","position":18,"is_corresponding":false},{"id":241108,"name":"Marc Suárez‐Calvet","orcid":"0000-0002-2993-569X","position":19,"is_corresponding":false},{"id":241105,"name":"Thomas K. Karikari","orcid":"0000-0003-1422-4358","position":20,"is_corresponding":false},{"id":27600,"name":"Kaj Blennow","orcid":"0000-0002-1890-4193","position":21,"is_corresponding":false},{"id":839573,"name":"Fernando González‐Ortiz","orcid":"0000-0001-7897-9456","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-19T01:06:44.698773Z","pmid":"37975513","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}