{"doi":"10.1002/alz.13523","title":"Personality predictors of dementia diagnosis and neuropathological burden: An individual participant data meta‐analysis","abstract":"INTRODUCTION: The extent to which the Big Five personality traits and subjective well-being (SWB) are discriminatory predictors of clinical manifestation of dementia versus dementia-related neuropathology is unclear. METHODS: range = 3.53 to 21.00 years), Bayesian multilevel models tested whether personality traits and SWB differentially predicted neuropsychological and neuropathological characteristics of dementia. RESULTS: Synthesized and individual study results indicate that high neuroticism and negative affect and low conscientiousness, extraversion, and positive affect were associated with increased risk of long-term dementia diagnosis. There were no consistent associations with neuropathology. DISCUSSION: This multistudy project provides robust, conceptually replicated and extended evidence that psychosocial factors are strong predictors of dementia diagnosis but not consistently associated with neuropathology at autopsy. HIGHLIGHTS: N(+), C(-), E(-), PA(-), and NA(+) were associated with incident diagnosis. Results were consistent despite self-report versus clinical diagnosis of dementia. Psychological factors were not associated with neuropathology at autopsy. Individuals with higher conscientiousness and no diagnosis had less neuropathology. High C individuals may withstand neuropathology for longer before death.","journal":"Alzheimer s & Dementia","year":2023,"id":326367,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9241,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":477023,"name":"Tomiko Yoneda","orcid":"0000-0002-2906-1881","position":1,"is_corresponding":false},{"id":321317,"name":"Bryan D. James","orcid":"0000-0003-1932-151X","position":2,"is_corresponding":false},{"id":778,"name":"David A. Bennett","orcid":"0000-0003-3689-554X","position":3,"is_corresponding":false},{"id":226993,"name":"Jason Hassenstab","orcid":"0000-0002-7802-3371","position":4,"is_corresponding":false},{"id":251473,"name":"Mindy J. Katz","orcid":"0009-0004-7524-0292","position":5,"is_corresponding":false},{"id":234917,"name":"Richard B. Lipton","orcid":"0000-0003-2652-2897","position":6,"is_corresponding":false},{"id":27593,"name":"John C. Morris","orcid":"0000-0001-9820-5618","position":7,"is_corresponding":false},{"id":321321,"name":"Daniel K. Mroczek","orcid":"0000-0003-3748-5059","position":8,"is_corresponding":false},{"id":321316,"name":"Eileen K Graham","orcid":"0000-0003-3095-4625","position":9,"is_corresponding":false},{"id":767830,"name":"Emorie D Beck","orcid":"0000-0002-8152-3510","position":0,"is_corresponding":true}],"reference_count":71,"raw_metadata":null,"created_at":"2026-07-19T01:08:33.106703Z","pmid":"38018701","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}