{"doi":"10.1002/alz.13446","title":"AT(N) biomarker profiles and Alzheimer's disease symptomology in Down syndrome","abstract":"INTRODUCTION: Down syndrome (DS) is a genetic cause of early-onset Alzheimer's disease (AD). The National Institute on Aging-Alzheimer's Association AT(N) Research Framework is a staging model for AD biomarkers but has not been assessed in DS. METHOD: F]AV-1451) were used to classify amyloid (A) -/+ and tau (T) +/-. Hippocampal volume classified neurodegeneration (N) -/+. The modified Cued Recall Test assessed episodic memory. RESULTS: Analyses included 162 adults with DS (aged M = 38.84 years, standard deviation = 8.41). Overall, 69.8% of participants were classified as A-/T-/(N)-, 11.1% were A+/T-/(N)-, 5.6% were A+/T+/(N)-, and 9.3% were A+/T+/(N)+. Participants deemed cognitively stable were most likely to be A-T-(N)- and A+T-(N)-. Tau PET (T+) most closely aligning with memory impairment and AD clinical status. DISCUSSION: Findings add to understanding of AT(N) biomarker profiles in DS. HIGHLIGHTS: Overall, 69.8% of adults with Down syndrome (DS) aged 25 to 61 years were classified as amyloid (A)-/tau (T)-/neurodegeneration (N)-, 11.1% were A+/T-/(N)-, 5.6% were A+/T+/(N)-, and 9.3% were A+/T+/(N)+. The AT(N) profiles were associated with clinical Alzheimer's disease (AD) status and with memory performance, with the presence of T+ aligned with AD clinical symptomology. Findings inform models for predicting the transition to the prodromal stage of AD in DS.","journal":"Alzheimer s & Dementia","year":2023,"id":328998,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7326,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":270459,"name":"Benjamin L. Handen","orcid":"0000-0001-9550-1665","position":1,"is_corresponding":false},{"id":270464,"name":"Dana Tudorascu","orcid":"0000-0003-4675-3692","position":2,"is_corresponding":false},{"id":750296,"name":"Laisze Lee","orcid":null,"position":3,"is_corresponding":false},{"id":272728,"name":"Annie Cohen","orcid":null,"position":4,"is_corresponding":false},{"id":737606,"name":"Emily K. Schworer","orcid":"0000-0002-5309-339X","position":5,"is_corresponding":false},{"id":271302,"name":"Jamie C. Peven","orcid":"0000-0002-2187-5514","position":6,"is_corresponding":false},{"id":459245,"name":"Matthew Zammit","orcid":"0000-0001-8966-8397","position":7,"is_corresponding":false},{"id":49958,"name":"William E. Klunk","orcid":"0000-0001-5512-0251","position":8,"is_corresponding":false},{"id":275732,"name":"Charles M. Laymon","orcid":"0000-0002-5966-7219","position":9,"is_corresponding":false},{"id":275735,"name":"Davneet Minhas","orcid":"0000-0002-0217-6777","position":10,"is_corresponding":false},{"id":1051527,"name":"Weiquan Luo","orcid":null,"position":11,"is_corresponding":false},{"id":232613,"name":"Shahid Zaman","orcid":"0000-0003-1639-6014","position":12,"is_corresponding":false},{"id":226074,"name":"Beau M. Ances","orcid":"0000-0003-3862-7397","position":13,"is_corresponding":false},{"id":701528,"name":"Gregory M. Preboske","orcid":null,"position":14,"is_corresponding":false},{"id":270461,"name":"Bradley T. Christian","orcid":"0000-0002-9653-559X","position":15,"is_corresponding":false},{"id":270471,"name":"Sigan L. Hartley","orcid":"0000-0002-0186-6282","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-19T01:08:56.940647Z","pmid":"37641428","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}