{"doi":"10.1002/alz.13444","title":"Characterizing the emergence of amyloid and tau burden in Down syndrome","abstract":"INTRODUCTION: Almost all individuals with Down syndrome (DS) will develop neuropathological features of Alzheimer's disease (AD). Understanding AD biomarker trajectories is necessary for DS-specific clinical interventions and interpretation of drug-related changes in the disease trajectory. METHODS: A total of 177 adults with DS from the Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) underwent positron emission tomography (PET) and MR imaging. Amyloid-beta (Aβ) trajectories were modeled to provide individual-level estimates of Aβ-positive (A+) chronicity, which were compared against longitudinal tau change. RESULTS: Elevated tau was observed in all NFT regions following A+ and longitudinal tau increased with respect to A+ chronicity. Tau increases in NFT regions I-III was observed 0-2.5 years following A+. Nearly all A+ individuals had tau increases in the medial temporal lobe. DISCUSSION: These findings highlight the rapid accumulation of amyloid and early onset of tau relative to amyloid in DS and provide a strategy for temporally characterizing AD neuropathology progression that is specific to the DS population and independent of chronological age. HIGHLIGHTS: Longitudinal amyloid trajectories reveal rapid Aβ accumulation in Down syndrome NFT stage tau was strongly associated with A+ chronicity Early longitudinal tau increases were observed 2.5-5 years after reaching A.","journal":"Alzheimer s & Dementia","year":2023,"id":318430,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":65,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6489,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":289688,"name":"Tobey J. Betthauser","orcid":"0000-0001-8856-1352","position":1,"is_corresponding":false},{"id":1025680,"name":"Andrew K McVea","orcid":"0009-0008-4525-2793","position":2,"is_corresponding":false},{"id":275732,"name":"Charles M. Laymon","orcid":"0000-0002-5966-7219","position":3,"is_corresponding":false},{"id":270464,"name":"Dana Tudorascu","orcid":"0000-0003-4675-3692","position":4,"is_corresponding":false},{"id":230038,"name":"Sterling C. Johnson","orcid":"0000-0002-8501-545X","position":5,"is_corresponding":false},{"id":270471,"name":"Sigan L. Hartley","orcid":"0000-0002-0186-6282","position":6,"is_corresponding":false},{"id":492024,"name":"Alexander K. Converse","orcid":"0000-0002-2035-9331","position":7,"is_corresponding":false},{"id":275735,"name":"Davneet Minhas","orcid":"0000-0002-0217-6777","position":8,"is_corresponding":false},{"id":232613,"name":"Shahid Zaman","orcid":"0000-0003-1639-6014","position":9,"is_corresponding":false},{"id":226074,"name":"Beau M. Ances","orcid":"0000-0003-3862-7397","position":10,"is_corresponding":false},{"id":290562,"name":"Charles K. Stone","orcid":null,"position":11,"is_corresponding":false},{"id":422875,"name":"Chester A. Mathis","orcid":"0000-0001-9811-0950","position":12,"is_corresponding":false},{"id":272728,"name":"Annie Cohen","orcid":null,"position":13,"is_corresponding":false},{"id":49958,"name":"William E. Klunk","orcid":"0000-0001-5512-0251","position":14,"is_corresponding":false},{"id":270459,"name":"Benjamin L. Handen","orcid":"0000-0001-9550-1665","position":15,"is_corresponding":false},{"id":270461,"name":"Bradley T. Christian","orcid":"0000-0002-9653-559X","position":16,"is_corresponding":false},{"id":459245,"name":"Matthew Zammit","orcid":"0000-0001-8966-8397","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":null,"created_at":"2026-07-19T01:07:01.300821Z","pmid":"37641577","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}