{"doi":"10.1002/alz.13367","title":"Serum NfL and GFAP are associated with incident dementia and dementia mortality in older adults: The cardiovascular health study","abstract":"INTRODUCTION: Circulating neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) have been independently associated with dementia risk. Their additive association, and their associations with dementia-specific mortality, have not been investigated. METHODS: We associated serum NfL, GFAP, total tau ,and ubiquitin carboxyl-terminal hydrolase-L1, measured in 1712 dementia-free adults, with 19-year incident dementia and dementia-specific mortality risk, and with 3-year cognitive decline. RESULTS: In adjusted models, being in the highest versus lowest tertile of NfL or GFAP associated with a hazard ratio (HR) of 1.49 (1.20-1.84) and 1.38 (1.15-1.66) for incident dementia, and 2.87 (1.79-4.61) and 2.76 (1.73-4.40) for dementia-specific mortality. Joint third versus first tertile exposure further increased risk; HR = 2.06 (1.60-2.67) and 9.22 (4.48-18.9). NfL was independently associated with accelerated cognitive decline. DISCUSSION: Circulating NfL and GFAP may, independently and jointly, provide useful clinical insight regarding dementia risk and prognosis.","journal":"Alzheimer s & Dementia","year":2023,"id":320610,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":48,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9045,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":970453,"name":"Xiaojuan Liu","orcid":"0000-0002-6429-5982","position":1,"is_corresponding":false},{"id":305264,"name":"Michelle C. Odden","orcid":"0000-0002-5974-3648","position":2,"is_corresponding":false},{"id":1031774,"name":"Kristine F. Moseholm","orcid":"0000-0002-8954-9846","position":3,"is_corresponding":false},{"id":17639,"name":"Sudha Seshadri","orcid":"0000-0001-6135-2622","position":4,"is_corresponding":false},{"id":245362,"name":"Claudia L. Satizábal","orcid":"0000-0002-1115-4430","position":5,"is_corresponding":false},{"id":245369,"name":"Oscar L. López","orcid":"0000-0002-8546-8256","position":6,"is_corresponding":false},{"id":17626,"name":"Joshua C. Bis","orcid":"0000-0002-3409-1110","position":7,"is_corresponding":false},{"id":98937,"name":"Luc Djoussé","orcid":"0000-0002-9902-3047","position":8,"is_corresponding":false},{"id":252369,"name":"Alison E. Fohner","orcid":"0000-0003-4231-3331","position":9,"is_corresponding":false},{"id":17625,"name":"Bruce M. Psaty","orcid":"0000-0002-7278-2190","position":10,"is_corresponding":false},{"id":25028,"name":"Russell P. Tracy","orcid":"0000-0002-0080-2420","position":11,"is_corresponding":false},{"id":17627,"name":"W.T. Longstreth","orcid":null,"position":12,"is_corresponding":false},{"id":347293,"name":"Majken K. Jensen","orcid":"0000-0003-4729-7545","position":13,"is_corresponding":false},{"id":291349,"name":"Kenneth J. Mukamal","orcid":"0000-0001-8450-6970","position":14,"is_corresponding":false},{"id":676616,"name":"Héléne T. Cronjé","orcid":"0000-0001-6855-8324","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-19T01:07:27.434133Z","pmid":"37392405","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}