{"doi":"10.1002/alz.13345","title":"White matter hyperintensity shape is associated with long‐term dementia risk","abstract":"INTRODUCTION: We aimed to investigate the association between white matter hyperintensity (WMH) shape and volume and the long-term dementia risk in community-dwelling older adults. METHODS: Three thousand seventy-seven participants (mean age: 75.6 ± 5.2 years) of the Age Gene/Environment Susceptibility (AGES)-Reykjavik study underwent baseline 1.5T brain magnetic resonance imaging and were followed up for dementia (mean follow-up: 9.9 ± 2.6 years). RESULTS: More irregular shape of periventricular/confluent WMH (lower solidity (hazard ratio (95% confidence interval) 1.34 (1.17 to 1.52), p < .001) and convexity 1.38 (1.28 to 1.49), p < .001); higher concavity index 1.43 (1.32 to 1.54), p < .001) and fractal dimension 1.45 (1.32 to 1.58), p < .001)), higher total WMH volume (1.68 (1.54 to 1.87), p < .001), higher periventricular/confluent WMH volume (1.71 (1.55 to 1.89), p < .001), and higher deep WMH volume (1.17 (1.08 to 1.27), p < .001) were associated with an increased long-term dementia risk. DISCUSSION: WMH shape markers may in the future be useful in determining patient prognosis and may aid in patient selection for future preventive treatments in community-dwelling older adults.","journal":"Alzheimer s & Dementia","year":2023,"id":325801,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9229,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":245366,"name":"Sigurður Sigurðsson","orcid":"0000-0001-5439-3389","position":1,"is_corresponding":false},{"id":1044130,"name":"Kelly Klaassen","orcid":"0000-0003-0035-2412","position":2,"is_corresponding":false},{"id":672451,"name":"Lydiane Hirschler","orcid":"0000-0003-2379-0861","position":3,"is_corresponding":false},{"id":245384,"name":"Mark A. van Buchem","orcid":"0000-0003-1881-1998","position":4,"is_corresponding":false},{"id":17636,"name":"Lenore J. Launer","orcid":"0000-0002-3238-7612","position":5,"is_corresponding":false},{"id":473240,"name":"Matthias J.P. van Osch","orcid":"0000-0001-7034-8959","position":6,"is_corresponding":false},{"id":22041,"name":"Vilmundur Guðnason","orcid":"0000-0001-5696-0084","position":7,"is_corresponding":false},{"id":1044131,"name":"Jeroen de Bresser","orcid":"0000-0003-0759-8407","position":8,"is_corresponding":false},{"id":1044129,"name":"Jasmin Annica Keller","orcid":"0000-0001-7075-7525","position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-19T01:08:28.266998Z","pmid":"37303267","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}