{"doi":"10.1002/alz.13118","title":"Blood tau‐PT217 contributes to the anesthesia/surgery‐induced delirium‐like behavior in aged mice","abstract":"INTRODUCTION: Blood phosphorylated tau at threonine 217 (tau-PT217) is a newly established biomarker for Alzheimer's disease and postoperative delirium in patients. However, the mechanisms and consequences of acute changes in blood tau-PT217 remain largely unknown. METHODS: We investigated the effects of anesthesia/surgery on blood tau-PT217 in aged mice, and evaluated the associated changes in B cell populations, neuronal excitability in anterior cingulate cortex, and delirium-like behavior using positron emission tomography imaging, nanoneedle technology, flow cytometry, electrophysiology, and behavioral tests. RESULTS: Anesthesia/surgery induced acute increases in blood tau-PT217 via enhanced generation in the lungs and release from B cells. Tau-PT217 might cross the blood-brain barrier, increasing neuronal excitability and inducing delirium-like behavior. B cell transfer and WS635, a mitochondrial function enhancer, mitigated the anesthesia/surgery-induced changes. DISCUSSION: Acute increases in blood tau-PT217 may contribute to brain dysfunction and postoperative delirium. Targeting B cells or mitochondrial function may have therapeutic potential for preventing or treating these conditions.","journal":"Alzheimer s & Dementia","year":2023,"id":320409,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":49,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.957,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":395038,"name":"Feng Liang","orcid":"0000-0002-2097-4828","position":1,"is_corresponding":false},{"id":329735,"name":"Ping Bai","orcid":"0000-0003-4587-8426","position":2,"is_corresponding":false},{"id":1031027,"name":"Chenghao Liu","orcid":"0000-0001-7923-6806","position":3,"is_corresponding":false},{"id":1031028,"name":"Miao Xu","orcid":"0000-0003-0639-711X","position":4,"is_corresponding":false},{"id":680617,"name":"Zhengwang Sun","orcid":"0000-0002-4486-018X","position":5,"is_corresponding":false},{"id":1031029,"name":"Wenjie Tian","orcid":"0009-0009-0174-7310","position":6,"is_corresponding":false},{"id":395040,"name":"Yuanlin Dong","orcid":"0000-0002-4760-0519","position":7,"is_corresponding":false},{"id":432014,"name":"Yiying Zhang","orcid":"0000-0001-9965-2276","position":8,"is_corresponding":false},{"id":659438,"name":"Qimin Quan","orcid":null,"position":9,"is_corresponding":false},{"id":108426,"name":"Ashok Khatri","orcid":"0000-0003-4740-3846","position":10,"is_corresponding":false},{"id":588736,"name":"Yuan Shen","orcid":"0000-0002-7811-1478","position":11,"is_corresponding":false},{"id":310904,"name":"Edward R. Marcantonio","orcid":"0000-0002-2911-4250","position":12,"is_corresponding":false},{"id":1031577,"name":"Gregory Crosby","orcid":null,"position":13,"is_corresponding":false},{"id":399379,"name":"Deborah J. Culley","orcid":"0000-0002-1003-2407","position":14,"is_corresponding":false},{"id":329739,"name":"Changning Wang","orcid":"0000-0002-2076-4193","position":15,"is_corresponding":false},{"id":260404,"name":"Guang Yang","orcid":"0000-0002-5739-9126","position":16,"is_corresponding":false},{"id":395041,"name":"Zhongcong Xie","orcid":"0000-0002-0720-1759","position":17,"is_corresponding":false},{"id":1031026,"name":"Jing Lu","orcid":"0000-0003-4468-7134","position":0,"is_corresponding":true}],"reference_count":80,"raw_metadata":null,"created_at":"2026-07-19T01:07:22.377587Z","pmid":"37249148","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}