{"doi":"10.1002/alz.13105","title":"Research diagnostic criteria for mild cognitive impairment with Lewy bodies: A systematic review and meta‐analysis","abstract":"INTRODUCTION: Operationalized research criteria for mild cognitive impairment with Lewy bodies (MCI-LB) were published in 2020. The aim of this systematic review and meta-analysis was to review the evidence for the diagnostic clinical features and biomarkers in MCI-LB set out in the criteria. METHODS: MEDLINE, PubMed, and Embase were searched on 9/28/22 for relevant articles. Articles were included if they presented original data reporting the rates of diagnostic features in MCI-LB. RESULTS: Fifty-seven articles were included. The meta-analysis supported the inclusion of the current clinical features in the diagnostic criteria. Evidence for striatal dopaminergic imaging and meta-iodobenzylguanidine cardiac scintigraphy, though limited, supports their inclusion. Quantitative electroencephalogram (EEG) and fluorodeoxyglucose positron emission tomography (PET) show promise as diagnostic biomarkers. DISCUSSION: The available evidence largely supports the current diagnostic criteria for MCI-LB. Further evidence will help refine the diagnostic criteria and understand how best to apply them in clinical practice and research. HIGHLIGHTS: A meta-analysis of the diagnostic features of MCI-LB was carried out. The four core clinical features were more common in MCI-LB than MCI-AD/stable MCI. Neuropsychiatric and autonomic features were also more common in MCI-LB. More evidence is needed for the proposed biomarkers. FDG-PET and quantitative EEG show promise as diagnostic biomarkers in MCI-LB.","journal":"Alzheimer s & Dementia","year":2023,"id":320048,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":51,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6124,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1029939,"name":"Claudia Carrarini","orcid":"0000-0003-0718-9929","position":1,"is_corresponding":false},{"id":252021,"name":"Daniel Ferreira","orcid":"0000-0001-9522-4338","position":2,"is_corresponding":false},{"id":1029940,"name":"Annegret Habich","orcid":"0000-0002-2267-1206","position":3,"is_corresponding":false},{"id":108593,"name":"Dag Aarsland","orcid":"0000-0001-6314-216X","position":4,"is_corresponding":false},{"id":693819,"name":"Claudio Babiloni","orcid":"0000-0002-5245-9839","position":5,"is_corresponding":false},{"id":440109,"name":"Ece Bayram","orcid":"0000-0002-6875-4242","position":6,"is_corresponding":false},{"id":707424,"name":"Joseph Kane","orcid":"0000-0002-8479-9977","position":7,"is_corresponding":false},{"id":108605,"name":"Simon J.G. Lewis","orcid":"0000-0002-4093-7071","position":8,"is_corresponding":false},{"id":233019,"name":"Andrea Pilotto","orcid":"0000-0003-2029-6606","position":9,"is_corresponding":false},{"id":108585,"name":"Alan Thomas","orcid":"0000-0002-6667-9533","position":10,"is_corresponding":false},{"id":108595,"name":"Laura Bonanni","orcid":"0000-0001-7443-9233","position":11,"is_corresponding":false},{"id":108596,"name":"Paul C. Donaghy","orcid":"0000-0001-7195-4846","position":0,"is_corresponding":true}],"reference_count":98,"raw_metadata":null,"created_at":"2026-07-19T01:07:17.361058Z","pmid":"37096339","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}