{"doi":"10.1002/alz.12984","title":"Dementia occurring over a 32‐year follow‐up attributable to hypertension observed at different ages: Implications for dementia prevention","abstract":"INTRODUCTION: The fraction of dementia attributable to hypertension might vary depending on the age of the population considered and the age through which dementia occurs. METHODS: In the Atherosclerosis Risk in Communities study, we quantified population attributable fractions (PAF) of dementia by age 80 and 90 from hypertension assessed at ages of 45-54 (n = 7572), 55-64 (n = 12,033), 65-74 (n = 6561), and 75-84 (n = 2086). RESULTS: The PAF for dementia by age 80 from all non-normal blood pressure at ages 45-54 was 15.3% (95% confidence interval [CI] = 6.9%-22.3%), 19.1% (95% CI = 9.9%-26.9%) at ages 55-64, and 19.9% (95% CI = -4.4%-38.5%) at ages 65-74. The strongest PAFs were from stage 2 hypertension (11.9%-21.3%). For dementia by age 90, PAFs from non-normal blood pressure up through age 75 were smaller (10.9%-13.8%), and non-significant by age 75-84. DISCUSSION: Interventions targeting hypertension even in early late life might reduce a sizeable proportion of dementia. HIGHLIGHTS: We estimated prospective population attributable risks of dementia for hypertension. 15%-20% of dementia cases by age 80 are from non-normal blood pressure (BP). Associations between hypertension and dementia persisted through age 75. Midlife to early late-life BP control might reduce a large proportion of dementia.","journal":"Alzheimer s & Dementia","year":2023,"id":340715,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9073,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":699682,"name":"A. Richey Sharrett","orcid":"0000-0002-8835-7770","position":1,"is_corresponding":false},{"id":397580,"name":"James Russell Pike","orcid":"0000-0002-6858-620X","position":2,"is_corresponding":false},{"id":328345,"name":"Rebecca F. Gottesman","orcid":"0000-0002-9504-1256","position":3,"is_corresponding":false},{"id":49955,"name":"David S. Knopman","orcid":"0000-0002-6544-066X","position":4,"is_corresponding":false},{"id":331036,"name":"Mark Lee","orcid":"0000-0001-8411-9735","position":5,"is_corresponding":false},{"id":98923,"name":"Pamela L. Lutsey","orcid":"0000-0002-1572-1340","position":6,"is_corresponding":false},{"id":370391,"name":"Priya Palta","orcid":null,"position":7,"is_corresponding":false},{"id":331917,"name":"B. Gwen Windham","orcid":"0000-0001-6240-5044","position":8,"is_corresponding":false},{"id":23021,"name":"Josef Coresh","orcid":"0000-0002-4598-0669","position":9,"is_corresponding":false},{"id":482269,"name":"Jennifer A. Deal","orcid":"0000-0002-6985-048X","position":10,"is_corresponding":false},{"id":334319,"name":"Jason R. Smith","orcid":"0000-0001-9764-5849","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-19T01:10:58.548803Z","pmid":"36808817","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}