{"doi":"10.1002/alz.12974","title":"Placental growth factor as a sensitive biomarker for vascular cognitive impairment","abstract":"INTRODUCTION: High-performing biomarkers measuring the vascular contributions to cognitive impairment and dementia are lacking. METHODS: Using a multi-site observational cohort study design, we examined the diagnostic accuracy of plasma placental growth factor (PlGF) within the MarkVCID Consortium (n = 335; CDR 0-1). Subjects underwent clinical evaluation, cognitive testing, MRI, and blood sampling as defined by Consortium protocols. RESULTS: In the prospective population of 335 subjects (72.2 ± 7.8 years of age, 49.3% female), plasma PlGF (pg/mL) shows an ordinal odds ratio (OR) of 1.16 (1.07-1.25; P = .0003) for increasing Fazekas score and ordinal OR of 1.22 (1.14-1.32; P < .0001) for functional cognitive impairment measured by the Clinical Dementia Rating scale. We achieved the primary study outcome of a site-independent association of plasma PlGF (pg/mL) with white matter injury and cognitive impairment in two of three study cohorts. Secondary outcomes using the full MarkVCID cohort demonstrated that plasma PlGF can significantly discriminate individuals with Fazekas ≥ 2 and CDR = 0.5 (area under the curve [AUC] = 0.74) and CDR = 1 (AUC = 0.89) from individuals with CDR = 0. DISCUSSION: Plasma PlGF measured by standardized immunoassay functions as a stable, reliable, diagnostic biomarker for cognitive impairment associated with substantial white matter burden.","journal":"Alzheimer s & Dementia","year":2023,"id":318486,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":64,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8306,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":314700,"name":"Fanny M. Elahi","orcid":"0000-0003-4663-4992","position":1,"is_corresponding":false},{"id":872229,"name":"Davis S. Chong","orcid":"0000-0002-2061-2843","position":2,"is_corresponding":false},{"id":779558,"name":"Hannah L. Radabaugh","orcid":"0000-0001-9820-9862","position":3,"is_corresponding":false},{"id":19292,"name":"Adam R. Ferguson","orcid":"0000-0001-7102-1608","position":4,"is_corresponding":false},{"id":277081,"name":"Pauline Maillard","orcid":"0000-0003-3516-6345","position":5,"is_corresponding":false},{"id":670340,"name":"Jeffrey F. Thompson","orcid":null,"position":6,"is_corresponding":false},{"id":322532,"name":"Gary A. Rosenberg","orcid":"0000-0001-7426-7064","position":7,"is_corresponding":false},{"id":288635,"name":"Abhay P. Sagare","orcid":"0000-0002-8178-3785","position":8,"is_corresponding":false},{"id":27596,"name":"Abhay Moghekar","orcid":"0000-0001-9464-1551","position":9,"is_corresponding":false},{"id":57482,"name":"Hanzhang Lu","orcid":"0000-0003-3871-1564","position":10,"is_corresponding":false},{"id":1025766,"name":"Tiffany Lee","orcid":"0000-0002-0032-0608","position":11,"is_corresponding":false},{"id":244992,"name":"Donna M. Wilcock","orcid":"0000-0003-3388-1564","position":12,"is_corresponding":false},{"id":245362,"name":"Claudia L. Satizábal","orcid":"0000-0002-1115-4430","position":13,"is_corresponding":false},{"id":25028,"name":"Russell P. Tracy","orcid":"0000-0002-0080-2420","position":14,"is_corresponding":false},{"id":17639,"name":"Sudha Seshadri","orcid":"0000-0001-6135-2622","position":15,"is_corresponding":false},{"id":466210,"name":"Kristin Schwab","orcid":"0000-0001-5723-9109","position":16,"is_corresponding":false},{"id":644178,"name":"Karl G. Helmer","orcid":"0000-0002-5113-6843","position":17,"is_corresponding":false},{"id":644177,"name":"Herpreet Singh","orcid":"0000-0003-3797-7301","position":18,"is_corresponding":false},{"id":366456,"name":"Pia Kivisäkk","orcid":"0000-0001-9708-7509","position":19,"is_corresponding":false},{"id":21074,"name":"S Greenberg","orcid":null,"position":20,"is_corresponding":false},{"id":316057,"name":"Charlie S. DeCarli","orcid":null,"position":21,"is_corresponding":false},{"id":253924,"name":"Joel H. Kramer","orcid":"0000-0002-2917-8297","position":22,"is_corresponding":false},{"id":314701,"name":"Jason D. Hinman","orcid":"0000-0002-0872-5044","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-19T01:07:01.300821Z","pmid":"36815663","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}