{"doi":"10.1002/alz.12962","title":"Sex differences in dementia risk and risk factors: Individual‐participant data analysis using 21 cohorts across six continents from the COSMIC consortium","abstract":"INTRODUCTION: Sex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethno-regional groups. METHODS: A total of 29,850 participants (58% women) from 21 cohorts across six continents were included in an individual participant data meta-analysis. Sex-specific hazard ratios (HRs), and women-to-men ratio of hazard ratios (RHRs) for associations between RFs and all-cause dementia were derived from mixed-effect Cox models. RESULTS: Incident dementia occurred in 2089 (66% women) participants over 4.6 years (median). Women had higher dementia risk (HR, 1.12 [1.02, 1.23]) than men, particularly in low- and lower-middle-income economies. Associations between longer education and former alcohol use with dementia risk (RHR, 1.01 [1.00, 1.03] per year, and 0.55 [0.38, 0.79], respectively) were stronger for men than women; otherwise, there were no discernible sex differences in other RFs. DISCUSSION: Dementia risk was higher in women than men, with possible variations by country-level income settings, but most RFs appear to work similarly in women and men.","journal":"Alzheimer s & Dementia","year":2023,"id":315873,"datarank":2.405667661774188,"base_score":4.867534450455582,"endowment":4.867534450455582,"self_citation_contribution":0.7301301675683375,"citation_network_contribution":1.6755374942058507,"self_endowment_contribution":0.7301301675683375,"citer_contribution":1.6755374942058507,"corpus_percentile":91.13483406822928,"corpus_rank":1147,"citation_count":129,"citer_count":100,"citers_with_citation_signal":68,"citers_with_endowment":68,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.8723,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":955158,"name":"Katie Harris","orcid":"0000-0003-2444-2869","position":1,"is_corresponding":false},{"id":251504,"name":"Darren M. 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