{"doi":"10.1002/alz.12841","title":"Plasma and CSF biomarkers in a memory clinic: Head‐to‐head comparison of phosphorylated tau immunoassays","abstract":"INTRODUCTION: Direct comparisons of the main blood phosphorylated tau immunoassays in memory clinic populations are needed to understand possible differences. METHODS: In the BIODEGMAR study, 197 participants presenting with cognitive complaints were classified into an Alzheimer's disease (AD) or a non-AD cerebrospinal fluid (CSF) profile group, according to their amyloid beta 42/ phosphorylated tau (Aβ42/p-tau) ratio. We performed a head-to-head comparison of nine plasma and nine CSF tau immunoassays and determined their accuracy to discriminate abnormal CSF Aβ42/p-tau ratio. RESULTS: All studied plasma tau biomarkers were significantly higher in the AD CSF profile group compared to the non-AD CSF profile group and significantly discriminated abnormal CSF Aβ42/p-tau ratio. For plasma p-tau biomarkers, the higher discrimination accuracy was shown by Janssen p-tau217 (r = 0.76; area under the curve [AUC] = 0.96), ADx p-tau181 (r = 0.73; AUC = 0.94), and Lilly p-tau217 (r = 0.73; AUC = 0.94). DISCUSSION: Several plasma p-tau biomarkers can be used in a specialized memory clinic as a stand-alone biomarker to detect biologically-defined AD. HIGHLIGHTS: Patients with an Alzheimer's disease cerebrospinal fluid (AD CSF) profile have higher plasma phosphorylated tau (p-tau) levels than the non-AD CSF profile group. All plasma p-tau biomarkers significantly discriminate patients with an AD CSF profile from the non-AD CSF profile group. Janssen p-tau217, ADx p-tau181, and Lilly p-tau217 in plasma show the highest accuracy to detect biologically defined AD. Janssen p-tau217, ADx p-tau181, Lilly p-tau217, Lilly p-tau181, and UGot p-tau231 in plasma show performances that are comparable to their CSF counterparts.","journal":"Alzheimer s & Dementia","year":2022,"id":232256,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":229,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9464,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":842006,"name":"Albert Puig‐Pijoan","orcid":"0000-0002-9848-3711","position":1,"is_corresponding":false},{"id":658015,"name":"Marta Milà‐Alomà","orcid":"0000-0002-5687-4597","position":2,"is_corresponding":false},{"id":843095,"name":"Aida Fernández‐Lebrero","orcid":null,"position":3,"is_corresponding":false},{"id":843096,"name":"Greta García‐Escobar","orcid":null,"position":4,"is_corresponding":false},{"id":839573,"name":"Fernando González‐Ortiz","orcid":"0000-0001-7897-9456","position":5,"is_corresponding":false},{"id":841866,"name":"Przemysław R. Kac","orcid":"0000-0001-5083-0924","position":6,"is_corresponding":false},{"id":805697,"name":"Wagner S. Brum","orcid":"0000-0002-9777-0559","position":7,"is_corresponding":false},{"id":273184,"name":"Andréa L. Benedet","orcid":null,"position":8,"is_corresponding":false},{"id":241106,"name":"Juan Lantero‐Rodriguez","orcid":"0000-0002-7426-678X","position":9,"is_corresponding":false},{"id":840977,"name":"Theresa A. Day","orcid":null,"position":10,"is_corresponding":false},{"id":843097,"name":"Jeroen Vanbrabant","orcid":null,"position":11,"is_corresponding":false},{"id":668060,"name":"Erik Stoops","orcid":"0000-0001-9989-4486","position":12,"is_corresponding":false},{"id":839577,"name":"Eugeen Vanmechelen","orcid":"0000-0002-9466-5366","position":13,"is_corresponding":false},{"id":353468,"name":"Gallen Triana‐Baltzer","orcid":"0000-0003-0612-1236","position":14,"is_corresponding":false},{"id":354770,"name":"Setareh Moughadam","orcid":null,"position":15,"is_corresponding":false},{"id":74385,"name":"Hartmuth C. Kolb","orcid":"0000-0003-2414-5792","position":16,"is_corresponding":false},{"id":839824,"name":"Paula Ortiz‐Romero","orcid":"0000-0002-6378-6763","position":17,"is_corresponding":false},{"id":241105,"name":"Thomas K. 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