{"doi":"10.1002/alz.12815","title":"Association of spermidine plasma levels with brain aging in a population‐based study","abstract":"INTRODUCTION: Supplementation with spermidine may support healthy aging, but elevated spermidine tissue levels were shown to be an indicator of Alzheimer's disease (AD). METHODS: Data from 659 participants (age range: 21-81 years) of the population-based Study of Health in Pomerania TREND were included. We investigated the association between spermidine plasma levels and markers of brain aging (hippocampal volume, AD score, global cortical thickness [CT], and white matter hyperintensities [WMH]). RESULTS: Higher spermidine levels were significantly associated with lower hippocampal volume (ß = -0.076; 95% confidence interval [CI]: -0.13 to -0.02; q = 0.026), higher AD score (ß = 0.118; 95% CI: 0.05 to 0.19; q = 0.006), lower global CT (ß = -0.104; 95% CI: -0.17 to -0.04; q = 0.014), but not WMH volume. Sensitivity analysis revealed no substantial changes after excluding participants with cancer, depression, or hemolysis. DISCUSSION: Elevated spermidine plasma levels are associated with advanced brain aging and might serve as potential early biomarker for AD and vascular brain pathology.","journal":"Alzheimer s & Dementia","year":2022,"id":245440,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7599,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":235032,"name":"Stefan Frenzel","orcid":"0000-0001-5087-5970","position":1,"is_corresponding":false},{"id":880054,"name":"Martin Bahls","orcid":"0000-0002-2016-5852","position":2,"is_corresponding":false},{"id":230029,"name":"Mohamad Habes","orcid":"0000-0001-9447-5805","position":3,"is_corresponding":false},{"id":235067,"name":"Katharina Wittfeld","orcid":"0000-0003-4383-5043","position":4,"is_corresponding":false},{"id":5305,"name":"Sandra Van der Auwera","orcid":"0000-0002-1757-7768","position":5,"is_corresponding":false},{"id":107782,"name":"Robin Bülow","orcid":"0000-0003-1884-5784","position":6,"is_corresponding":false},{"id":880055,"name":"Stephanie Zylla","orcid":"0000-0001-7417-4407","position":7,"is_corresponding":false},{"id":2346,"name":"Nele Friedrich","orcid":"0000-0002-1017-7622","position":8,"is_corresponding":false},{"id":2347,"name":"Matthias Nauck","orcid":"0000-0002-6678-7964","position":9,"is_corresponding":false},{"id":5359,"name":"Henry Völzke","orcid":"0000-0001-7003-399X","position":10,"is_corresponding":false},{"id":5329,"name":"Hans J. Grabe","orcid":"0000-0003-3684-4208","position":11,"is_corresponding":false},{"id":880056,"name":"Claudia Schwarz","orcid":"0000-0003-3234-912X","position":12,"is_corresponding":false},{"id":694782,"name":"Agnes Flöel","orcid":"0000-0002-1475-5872","position":13,"is_corresponding":false},{"id":880053,"name":"Silke M. Wortha","orcid":"0000-0001-9160-1175","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-19T00:23:34.974895Z","pmid":"36321615","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}