{"doi":"10.1002/alz.12725","title":"Elevated blood pressure is associated with advanced brain aging in mid‐life: A 30‐year follow‐up of The CARDIA Study","abstract":"BACKGROUND: High blood pressure (BP) is a risk factor for late-life brain health; however, the association of elevated BP with brain health in mid-life is unclear. METHODS: We identified 661 participants from the Coronary Artery Risk Development in Young Adults Study (age 18-30 at baseline) with 30 years of follow-up and brain magnetic resonance imaging at year 30. Cumulative exposure of BP was estimated by time-weighted averages (TWA). Ideal cardiovascular health was defined as systolic BP < 120 mm Hg, diastolic BP < 80 mm Hg. Brain age was calculated using previously validated high dimensional machine learning pattern analyses. RESULTS: Every 5 mmHg increment in TWA systolic BP was associated with approximately 1-year greater brain age (95% confidence interval [CI]: 0.50-1.36) Participants with TWA systolic or diastolic BP over the recommended guidelines for ideal cardiovascular health, had on average 3-year greater brain age (95% CI: 1.00-4.67; 95% CI: 1.45-5.13, respectively). CONCLUSION: Elevated BP from early to mid adulthood, even below clinical cut-offs, is associated with advanced brain aging in mid-life.","journal":"Alzheimer s & Dementia","year":2022,"id":245401,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5002,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":230029,"name":"Mohamad Habes","orcid":"0000-0001-9447-5805","position":1,"is_corresponding":false},{"id":34929,"name":"Guray Erus","orcid":"0000-0001-6633-4861","position":2,"is_corresponding":false},{"id":252183,"name":"Eric Vittinghoff","orcid":"0000-0001-8535-0920","position":3,"is_corresponding":false},{"id":34918,"name":"Christos Davatzikos","orcid":"0000-0002-1025-8561","position":4,"is_corresponding":false},{"id":230030,"name":"Ilya M. Nasrallah","orcid":"0000-0003-2346-7562","position":5,"is_corresponding":false},{"id":17636,"name":"Lenore J. Launer","orcid":"0000-0002-3238-7612","position":6,"is_corresponding":false},{"id":305267,"name":"Stephen Sidney","orcid":"0000-0001-7454-5036","position":7,"is_corresponding":false},{"id":55010,"name":"Kristine Yaffe","orcid":"0000-0003-0919-3825","position":8,"is_corresponding":false},{"id":348132,"name":"Christina S. Dintica","orcid":"0000-0001-8186-8140","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T00:23:34.974895Z","pmid":"35779250","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}