{"doi":"10.1002/alz.12714","title":"The landscape of metabolic brain alterations in Alzheimer's disease","abstract":"INTRODUCTION: Alzheimer's disease (AD) is accompanied by metabolic alterations both in the periphery and the central nervous system. However, so far, a global view of AD-associated metabolic changes in the brain has been missing. METHODS: We metabolically profiled 500 samples from the dorsolateral prefrontal cortex. Metabolite levels were correlated with eight clinical parameters, covering both late-life cognitive performance and AD neuropathology measures. RESULTS: We observed widespread metabolic dysregulation associated with AD, spanning 298 metabolites from various AD-relevant pathways. These included alterations to bioenergetics, cholesterol metabolism, neuroinflammation, and metabolic consequences of neurotransmitter ratio imbalances. Our findings further suggest impaired osmoregulation as a potential pathomechanism in AD. Finally, inspecting the interplay of proteinopathies provided evidence that metabolic associations were largely driven by tau pathology rather than amyloid beta pathology. DISCUSSION: This work provides a comprehensive reference map of metabolic brain changes in AD that lays the foundation for future mechanistic follow-up studies.","journal":"Alzheimer s & Dementia","year":2022,"id":234626,"datarank":1.6246513588405231,"base_score":4.553876891600541,"endowment":4.553876891600541,"self_citation_contribution":0.6830815337400812,"citation_network_contribution":0.9415698251004421,"self_endowment_contribution":0.6830815337400812,"citer_contribution":0.9415698251004421,"corpus_percentile":null,"corpus_rank":null,"citation_count":94,"citer_count":66,"citers_with_citation_signal":40,"citers_with_endowment":40,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6483,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":244565,"name":"Matthias Arnold","orcid":"0000-0002-4666-0923","position":1,"is_corresponding":false},{"id":806232,"name":"Maria A. Wörheide","orcid":null,"position":2,"is_corresponding":false},{"id":232915,"name":"Mariet Allen","orcid":"0000-0002-2685-427X","position":3,"is_corresponding":false},{"id":230880,"name":"Xue Wang","orcid":"0000-0003-1964-4124","position":4,"is_corresponding":false},{"id":244571,"name":"Colette Blach","orcid":"0000-0003-1264-0614","position":5,"is_corresponding":false},{"id":68010,"name":"Allan I. Levey","orcid":"0000-0002-3153-502X","position":6,"is_corresponding":false},{"id":21539,"name":"Nicholas T. Seyfried","orcid":"0000-0002-4507-624X","position":7,"is_corresponding":false},{"id":776,"name":"Nilüfer Ertekin‐Taner","orcid":"0000-0003-4436-8889","position":8,"is_corresponding":false},{"id":778,"name":"David A. Bennett","orcid":"0000-0003-3689-554X","position":9,"is_corresponding":false},{"id":2353,"name":"Gabi Kastenmüller","orcid":"0000-0002-2368-7322","position":10,"is_corresponding":false},{"id":75183,"name":"Rima Kaddurah‐Daouk","orcid":"0000-0003-1858-5732","position":11,"is_corresponding":false},{"id":2337,"name":"Jan Krumsiek","orcid":"0000-0003-4734-3791","position":12,"is_corresponding":false},{"id":1248,"name":"Richa Batra","orcid":"0000-0003-3708-0086","position":0,"is_corresponding":true}],"reference_count":99,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:21:42.662304Z","pmid":"35829654","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}