{"doi":"10.1002/alz.12712","title":"Traumatic brain injury and post‐traumatic stress disorder are not associated with Alzheimer's disease pathology measured with biomarkers","abstract":"INTRODUCTION: Epidemiological studies report an association between traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) and clinically diagnosed Alzheimer's disease (AD). We examined the association between TBI/PTSD and biomarker-defined AD. METHODS: We identified 289 non-demented veterans with TBI and/or PTSD and controls who underwent clinical evaluation, cerebrospinal fluid (CSF) collection, magnetic resonance imaging (MRI), amyloid beta (Aβ) and tau positron emission tomography, and apolipoprotein E testing. Participants were followed for up to 5.2 years. RESULTS: Exposure groups (TBI, PTSD, and TBI + PTSD) had higher prevalence of mild cognitive impairment (MCI: P < .0001) and worse Mini-Mental State Examination scores (PTSD: P = .008; TBI & PTSD: P = .009) than controls. There were no significant differences in other cognitive scores, MRI volumes, Aβ or tau accumulation, or in most longitudinal measures. DISCUSSION: TBI and/or PTSD were not associated with elevated AD biomarkers. The poorer cognitive status of exposed veterans may be due to other comorbid pathologies.","journal":"Alzheimer s & Dementia","year":2022,"id":238886,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":52,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8882,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":226055,"name":"Danielle Harvey","orcid":"0000-0002-5367-0951","position":1,"is_corresponding":false},{"id":66310,"name":"Susan Landau","orcid":null,"position":2,"is_corresponding":false},{"id":51703,"name":"Dallas P. Veitch","orcid":"0000-0002-9918-0640","position":3,"is_corresponding":false},{"id":392841,"name":"Thomas C. Neylan","orcid":"0000-0002-1572-2626","position":4,"is_corresponding":false},{"id":305020,"name":"Jordan Grafman","orcid":"0000-0001-8645-4457","position":5,"is_corresponding":false},{"id":229340,"name":"Paul Aisen","orcid":null,"position":6,"is_corresponding":false},{"id":27599,"name":"Ronald C. Petersen","orcid":"0000-0002-8178-6601","position":7,"is_corresponding":false},{"id":49956,"name":"Clifford R. Jack","orcid":"0000-0001-7916-622X","position":8,"is_corresponding":false},{"id":642769,"name":"Duygu Tosun","orcid":"0000-0001-5174-3910","position":9,"is_corresponding":false},{"id":27605,"name":"Leslie M. Shaw","orcid":"0000-0002-7650-1210","position":10,"is_corresponding":false},{"id":27606,"name":"John Q. Trojanowski","orcid":"0000-0002-9239-8794","position":11,"is_corresponding":false},{"id":27595,"name":"Andrew J. Saykin","orcid":"0000-0002-1376-8532","position":12,"is_corresponding":false},{"id":863445,"name":"Jacqueline Hayes","orcid":"0000-0002-2042-8237","position":13,"is_corresponding":false},{"id":864088,"name":"Charles De Carli","orcid":null,"position":14,"is_corresponding":false},{"id":51702,"name":"Michael W. Weiner","orcid":"0000-0002-0144-1954","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-19T00:22:31.741535Z","pmid":"35768339","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}