{"doi":"10.1002/alz.12677","title":"Modifying effects of race and ethnicity and <i>APOE</i> on the association of physical activity with risk of Alzheimer's disease and related dementias","abstract":"INTRODUCTION: We investigated whether the protective association of physical activity with risk of Alzheimer's disease and related dementias (ADRD) has genetic or behavioral variations. METHODS: In the Multiethnic Cohort, we analyzed moderate or vigorous physical activity (MVPA) reported at ages 45 to 75 among 88,047 participants in relation to 13,039 incident diagnoses of late-onset ADRD identified in Medicare claims (1999 to 2014), by five racial and ethnic groups, hours sitting, and in a subset (16%), apolipoprotein E (APOE) genotype. RESULTS: MVPA was inversely associated with ADRD (hazard ratio for ≥14 vs <2.5 hours/week: 0.83, 95% confidence interval [CI]: 0.76 to 0.90 in men; 0.88, 5% CI: 0.81 to 0.95 in women). The association was inverse in all racial and ethnic groups except Black participants (P-heterogeneity = 0.52), but stronger in individuals with lower levels of sitting duration or those who do not carry the APOE e4 risk allele. DISCUSSION: The different effects of physical activity by sitting duration and APOE genotype warrant further research.","journal":"Alzheimer s & Dementia","year":2022,"id":259751,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9051,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":305549,"name":"Veronica Wendy Setiawan","orcid":"0000-0001-9239-5692","position":1,"is_corresponding":false},{"id":321296,"name":"Lon R. White","orcid":"0000-0002-5536-3867","position":2,"is_corresponding":false},{"id":33583,"name":"Anna H. Wu","orcid":"0000-0003-0546-902X","position":3,"is_corresponding":false},{"id":252204,"name":"Iona Cheng","orcid":"0000-0003-4132-2893","position":4,"is_corresponding":false},{"id":11270,"name":"Christopher A. Haiman","orcid":"0000-0002-0097-9971","position":5,"is_corresponding":false},{"id":11264,"name":"Lynne R. Wilkens","orcid":"0000-0001-8408-4536","position":6,"is_corresponding":false},{"id":912880,"name":"Loїc Le Marchand","orcid":null,"position":7,"is_corresponding":false},{"id":21705,"name":"Unhee Lim","orcid":"0000-0001-6221-7190","position":8,"is_corresponding":false},{"id":348029,"name":"Song‐Yi Park","orcid":"0000-0001-7734-5320","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-19T00:25:58.993402Z","pmid":"35476309","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}