{"doi":"10.1002/alz.12628","title":"Dose‐response relationship between late‐life physical activity and incident dementia: A pooled analysis of 10 cohort studies of memory in an international consortium","abstract":"INTRODUCTION: Though consistent evidence suggests that physical activity may delay dementia onset, the duration and amount of activity required remains unclear. METHODS: We harmonized longitudinal data of 11,988 participants from 10 cohorts in eight countries to examine the dose-response relationship between late-life physical activity and incident dementia among older adults. RESULTS: Using no physical activity as a reference, dementia risk decreased with duration of physical activity up to 3.1 to 6.0 hours/week (hazard ratio [HR] 0.88, 95% confidence interval [CI] 0.67 to 1.15 for 0.1 to 3.0 hours/week; HR 0.68, 95% CI 0.52 to 0.89 for 3.1 to 6.0 hours/week), but plateaued with higher duration. For the amount of physical activity, a similar pattern of dose-response curve was observed, with an inflection point of 9.1 to 18.0 metabolic equivalent value (MET)-hours/week (HR 0.92, 95% CI 0.70 to 1.22 for 0.1 to 9.0 MET-hours/week; HR 0.70, 95% CI 0.53 to 0.93 for 9.1 to 18.0 MET-hours/week). DISCUSSION: This cross-national analysis suggests that performing 3.1 to 6.0 hours of physical activity and expending 9.1 to 18.0/MET-hours of energy per week may reduce dementia risk.","journal":"Alzheimer s & Dementia","year":2022,"id":248833,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9516,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":888409,"name":"Ding Ding","orcid":"0000-0002-0352-0883","position":1,"is_corresponding":false},{"id":328761,"name":"Qianhua Zhao","orcid":"0000-0001-5655-158X","position":2,"is_corresponding":false},{"id":888410,"name":"Zhenxu Xiao","orcid":"0000-0002-6598-0367","position":3,"is_corresponding":false},{"id":888411,"name":"Jianfeng Luo","orcid":"0000-0002-9833-0416","position":4,"is_corresponding":false},{"id":251490,"name":"Mary Ganguli","orcid":"0000-0003-2762-7105","position":5,"is_corresponding":false},{"id":380414,"name":"Tiffany F. 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Haan","orcid":"0000-0001-9312-4501","position":8,"is_corresponding":false},{"id":888921,"name":"Kristine van Dang","orcid":null,"position":9,"is_corresponding":false},{"id":39491,"name":"Maria Fernanda Lima‐Costa","orcid":"0000-0002-3474-2980","position":10,"is_corresponding":false},{"id":845867,"name":"Sérgio Luís Blay","orcid":"0000-0002-0568-9375","position":11,"is_corresponding":false},{"id":888922,"name":"Erico de Castro‐Costa","orcid":null,"position":12,"is_corresponding":false},{"id":251497,"name":"Tze Pin Ng","orcid":"0000-0001-9585-855X","position":13,"is_corresponding":false},{"id":251499,"name":"Xinyi Gwee","orcid":"0000-0003-3570-1352","position":14,"is_corresponding":false},{"id":251498,"name":"Qi Gao","orcid":"0000-0002-1965-7411","position":15,"is_corresponding":false},{"id":38718,"name":"Oye Gureje","orcid":"0000-0003-0094-5947","position":16,"is_corresponding":false},{"id":626156,"name":"Akin Ojagbemi","orcid":"0000-0001-7612-8017","position":17,"is_corresponding":false},{"id":888412,"name":"Toyin Bello","orcid":"0000-0002-3121-3290","position":18,"is_corresponding":false},{"id":251486,"name":"Suzana Shahar","orcid":"0000-0002-7191-9212","position":19,"is_corresponding":false},{"id":888413,"name":"Arimi Fitri Mat Ludin","orcid":"0000-0003-1517-2115","position":20,"is_corresponding":false},{"id":888414,"name":"Nurul Fatin Malek Rivan","orcid":"0000-0002-7237-2319","position":21,"is_corresponding":false},{"id":328759,"name":"Nikolaos Scarmeas","orcid":"0000-0001-6453-8908","position":22,"is_corresponding":false},{"id":888415,"name":"Costas A. 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