{"doi":"10.1002/alz.12560","title":"Race, sex, and mid‐life changes in brain health: Cardia MRI substudy","abstract":"OBJECTIVE: To examine longitudinal race and sex differences in mid-life brain health and to evaluate whether cardiovascular health (CVH) or apolipoprotein E (APOE) ε4 explain differences. METHODS: The study included 478 Black and White participants (mean age: 50 years). Total (TBV), gray (GMV), white (WMV), and white matter hyperintensity (WMH) volumes and GM-cerebral blood flow (CBF) were acquired with 3T-magnetic resonance imaging at baseline and 5-year follow-up. Analyses were based on general linear models. RESULTS: There were race x sex interactions for GMV (P-interaction = .004) and CBF (P-interaction = .01) such that men showed more decline than women, and this was most evident in Blacks. Blacks compared to Whites had a significantly greater increase in WMH (P = .002). All sex-race differences in change were marginally attenuated by CVH and APOE ε4. CONCLUSION: Race-sex differences in brain health emerge by mid-life. Identifying new environmental factors beyond CVH is needed to develop early interventions to maintain brain health.","journal":"Alzheimer s & Dementia","year":2022,"id":253199,"datarank":0.6995444872147786,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"self_citation_contribution":0.47032413238937254,"citation_network_contribution":0.22922035482540604,"self_endowment_contribution":0.47032413238937254,"citer_contribution":0.22922035482540604,"corpus_percentile":71.41641525489285,"corpus_rank":3696,"citation_count":22,"citer_count":14,"citers_with_citation_signal":8,"citers_with_endowment":8,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.6402,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":230030,"name":"Ilya M. Nasrallah","orcid":"0000-0003-2346-7562","position":1,"is_corresponding":false},{"id":301392,"name":"John A. Detre","orcid":"0000-0002-8115-6343","position":2,"is_corresponding":false},{"id":647824,"name":"Sudipto Dolui","orcid":"0000-0002-9035-3795","position":3,"is_corresponding":false},{"id":34929,"name":"Guray Erus","orcid":"0000-0001-6633-4861","position":4,"is_corresponding":false},{"id":34918,"name":"Christos Davatzikos","orcid":"0000-0002-1025-8561","position":5,"is_corresponding":false},{"id":55677,"name":"Osorio Meirelles","orcid":"0000-0002-1124-5113","position":6,"is_corresponding":false},{"id":245385,"name":"R. Nick Bryan","orcid":"0000-0002-2327-4579","position":7,"is_corresponding":false},{"id":17636,"name":"Lenore J. Launer","orcid":"0000-0002-3238-7612","position":8,"is_corresponding":false},{"id":363675,"name":"Justine Moonen","orcid":"0000-0001-8260-8762","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-19T00:24:55.325369Z","pmid":"35142033","pmcid":"PMC9360196","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}