{"doi":"10.1002/alz.12486","title":"Personalized nutrition for dementia prevention","abstract":"<jats:title>Abstract</jats:title><jats:p>The role of nutrition has been investigated for decades under the assumption of one‐size‐fits‐all. Yet there is heterogeneity in metabolic and neurobiological responses to diet. Thus a more personalized approach may better fit biological reality and have increased efficacy to prevent dementia. Personalized nutrition builds on the food exposome, defined as the history of diet‐related exposures over the lifetime, and on its interactions with the genome and other biological characteristics (eg, metabolism, the microbiome) to shape health. We review current advances of personalized nutrition in dementia research. We discuss key questions, success milestones, and future roadmap from observational epidemiology to clinical studies through basic science. A personalized nutrition approach based on the best prescription for the most appropriate target population in the most relevant time‐window has the potential to strengthen dementia‐prevention efforts.</jats:p>","journal":"Alzheimer's &amp; Dementia","year":2022,"id":623310,"datarank":0.5676284450877392,"base_score":3.784189633918261,"endowment":3.784189633918261,"self_citation_contribution":0.5676284450877392,"citation_network_contribution":0.0,"self_endowment_contribution":0.5676284450877392,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":43,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":400000,"name":"Hussein N. Yassine","orcid":"0000-0002-2483-649X","position":1,"is_corresponding":false},{"id":843598,"name":"Debora Melo van Lent","orcid":"0000-0002-7392-9289","position":2,"is_corresponding":false},{"id":1610800,"name":"Sophie Lefèvre‐Arbogast","orcid":null,"position":3,"is_corresponding":false},{"id":1256376,"name":"Ondine van de Rest","orcid":"0000-0002-4632-7418","position":4,"is_corresponding":false},{"id":848436,"name":"Gene L. 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Personalized nutrition builds on the food exposome, defined as the history of diet‐related exposures over the lifetime, and on its interactions with the genome and other biological characteristics (eg, metabolism, the microbiome) to shape health. We review current advances of personalized nutrition in dementia research. We discuss key questions, success milestones, and future roadmap from observational epidemiology to clinical studies through basic science. A personalized nutrition approach based on the best prescription for the most appropriate target population in the most relevant time‐window has the potential to strengthen dementia‐prevention efforts.</jats:p>","is_dataset_classified":null,"base_score":3.784189633918261,"endowment":3.784189633918261,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34757699","pmcid":null,"openalex_id":"https://openalex.org/W3213657328","authors":[],"funders":[{"funder_name":"NIA NIH HHS","grant_id":"R01 AG054434","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R21 AG056518","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG043398","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG055770","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R03 AG067062","title":null},{"funder_name":"NCCIH NIH HHS","grant_id":"R90 AT008924","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG067063","title":null}],"total_grants":7,"fwci":3.9373,"citation_percentile":0.94584765,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":7},{"year":2023,"count":5},{"year":2024,"count":13},{"year":2025,"count":12},{"year":2026,"count":5}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/alz.12486","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/alz.12486","host_type":"publisher"},{"url":"https://alz-journals.onlinelibrary.wiley.com/doi/pdf/10.1002/alz.12486","host_type":"publisher"},{"url":"https://doi.org/10.1002/alz.12486","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34757699","host_type":"repository"},{"url":"https://hal.science/hal-03528345","host_type":"repository"},{"url":"https://oskar-bordeaux.fr/handle/20.500.12278/124404","host_type":"repository"},{"url":"https://research.wur.nl/en/publications/personalized-nutrition-for-dementia-prevention","host_type":"repository"}],"fields_of_study":["Nutrition, Genetics, and Disease","Nutritional Studies and Diet","Diet and metabolism studies","Dementia","Diet","Humans","Nutrigenomics","Nutritional Status","Precision Medicine"],"mesh_terms":["Dementia","Diet","Humans","Nutritional Status","Nutrigenomics","Precision Medicine"],"keywords":["Dementia","Exposome","Observational study","Personalized medicine","Microbiome","Medicine","Gerontology","Psychology","Bioinformatics","Disease","Biology","Environmental health","Pathology","Diet","Nutrition","Prevention","Precision Medicine","Risk Factors In Epidemiology","Precision Nutrition","Individualized Prevention"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T23:13:58.635150Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}