{"doi":"10.1002/alz.12378","title":"Effect of periodontal treatment on preclinical Alzheimer's disease—Results of a trial emulation approach","abstract":"INTRODUCTION: We investigated the relationship between periodontal treatment and pre-clinical Alzheimer's disease (AD). METHODS: In this quasi-experimental design, 177 periodontally treated patients from the \"Greifswald Approach to Individualized Medicine\" cohort, which used the same protocols as the population-based Study of Health in Pomerania TREND (SHIP-TREND), and 409 untreated subjects from SHIP-TREND were analyzed. Subjects were younger than 60 years at the magnetic resonance imaging examination, with a median observation period of 7.3 years. Imaging markers for brain atrophy in late-onset AD and brain aging were used as the outcomes. RESULTS: Robust to sensitivity analyses, periodontal treatment had a favorable effect on AD-related brain atrophy (-0.41; 95% confidence interval: -0.70 to -0.12; P = .0051), which corresponds to a shift from the 50th to the 37th percentile of the outcome distribution. For brain aging, the treatment effect was uncertain. CONCLUSION: Periodontitis is related to pre-clinical AD in our population.","journal":"Alzheimer s & Dementia","year":2021,"id":150101,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":97,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8878,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":235032,"name":"Stefan Frenzel","orcid":"0000-0001-5087-5970","position":1,"is_corresponding":false},{"id":136037,"name":"Birte Holtfreter","orcid":"0000-0002-6541-3127","position":2,"is_corresponding":false},{"id":5305,"name":"Sandra Van der Auwera","orcid":"0000-0002-1757-7768","position":3,"is_corresponding":false},{"id":638290,"name":"Christiane Pink","orcid":"0000-0001-5950-2716","position":4,"is_corresponding":false},{"id":107782,"name":"Robin Bülow","orcid":"0000-0003-1884-5784","position":5,"is_corresponding":false},{"id":2346,"name":"Nele Friedrich","orcid":"0000-0002-1017-7622","position":6,"is_corresponding":false},{"id":5359,"name":"Henry Völzke","orcid":"0000-0001-7003-399X","position":7,"is_corresponding":false},{"id":21857,"name":"Reiner Biffar","orcid":"0000-0002-0181-1388","position":8,"is_corresponding":false},{"id":136035,"name":"Thomas Kocher","orcid":"0000-0001-9605-2822","position":9,"is_corresponding":false},{"id":5329,"name":"Hans J. Grabe","orcid":"0000-0003-3684-4208","position":10,"is_corresponding":false},{"id":300139,"name":"for the Alzheimer's Disease Neuroimaging Initiative","orcid":null,"position":11,"is_corresponding":false},{"id":638289,"name":"Christian Schwahn","orcid":"0000-0003-4517-9326","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-18T23:43:01.325389Z","pmid":"34050719","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}