{"doi":"10.1002/alz.12367","title":"Body mass index in early adulthood and dementia in late life: Findings from a pooled cohort","abstract":"INTRODUCTION: To examine the independent association of body mass index (BMI) in early adulthood with dementia incidence among men and women. METHODS: We studied 5104 older adults from the Cardiovascular Health Study (CHS) and the Health, Aging, and Body Composition (Health ABC) study. We imputed early adulthood and midlife BMI using a pooled parent cohort with complete adult lifespan coverage and previously established methods. Dementia was ascertained using criteria such as neuropsychological test battery, medical records, and dementia-related drug use. Pooled logistic regression (PLR) models were used. RESULTS: Compared to women with normal BMI in early adulthood, the odds of dementia were higher among both overweight (odds ratio [OR] = 1.8; 95% confidence interval [CI] = 1.31 to 2.54) and obese (OR = 2.45; 95% CI = 1.47 to 4.06) women, independent of mid- and late-life BMI. Similar relationship was observed in men. CONCLUSIONS: With the growing obesity epidemic among US adults, efforts aimed at reducing dementia may need to begin obesity prevention and treatment early in the life course.","journal":"Alzheimer s & Dementia","year":2021,"id":165326,"datarank":1.3457381730279177,"base_score":3.6109179126442243,"endowment":3.6109179126442243,"self_citation_contribution":0.5416376868966337,"citation_network_contribution":0.8041004861312838,"self_endowment_contribution":0.5416376868966337,"citer_contribution":0.8041004861312838,"corpus_percentile":84.69869265877621,"corpus_rank":1979,"citation_count":36,"citer_count":28,"citers_with_citation_signal":25,"citers_with_endowment":25,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.7537,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":252183,"name":"Eric Vittinghoff","orcid":"0000-0001-8535-0920","position":1,"is_corresponding":false},{"id":688846,"name":"Tina Hoang","orcid":null,"position":2,"is_corresponding":false},{"id":328150,"name":"Sherita Hill Golden","orcid":"0000-0001-8854-4026","position":3,"is_corresponding":false},{"id":280710,"name":"Annette L. Fitzpatrick","orcid":"0000-0003-1941-6586","position":4,"is_corresponding":false},{"id":688847,"name":"Adina Zhang","orcid":null,"position":5,"is_corresponding":false},{"id":688367,"name":"Leslie Grasset","orcid":"0000-0003-2812-0103","position":6,"is_corresponding":false},{"id":55010,"name":"Kristine Yaffe","orcid":"0000-0003-0919-3825","position":7,"is_corresponding":false},{"id":305268,"name":"Adina Zeki Al Hazzouri","orcid":"0000-0002-6006-321X","position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-18T23:45:36.425208Z","pmid":"33984188","pmcid":"PMC8809510","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}