{"doi":"10.1002/alz.12359","title":"Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype","abstract":"INTRODUCTION: There is limited and inconsistent reporting on the association between Life's Simple 7 (LS7) and dementia in the elderly population. METHODS: Based on the Washington Heights-Inwood Columbia Aging Project (WHICAP), LS7 scores were estimated to assess cardiovascular health status. Associations between LS7 scores and incident dementia were investigated by Cox proportional hazards models. RESULTS: Among 1987 subjects, 291 incident cases of dementia were identified over a median follow-up of 5.84 years. Compared with subjects in the poor cardiovascular health group (scores 0 to 5), those in intermediate (6 to 9) and optimal (10 to 14) groups had lower dementia risk, with the hazard ratio (HR; 95% confidence interval) being 0.74 (0.54 to 1.00) and 0.59 (0.38 to 0.91), respectively. These results were significant in apolipoprotein E genotype ε4 (APOE ε4) allele non-carriers but not in carriers. DISCUSSION: Higher LS7 scores are protective for dementia, especially among the APOE ε4 noncarriers.","journal":"Alzheimer s & Dementia","year":2021,"id":156474,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":54,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9239,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":270469,"name":"Adam M. Brickman","orcid":"0000-0002-5125-8226","position":1,"is_corresponding":false},{"id":49960,"name":"Jennifer J. Manly","orcid":"0000-0002-9481-7497","position":2,"is_corresponding":false},{"id":355816,"name":"Christiane Reitz","orcid":"0000-0001-8757-7889","position":3,"is_corresponding":false},{"id":266059,"name":"Nicole Schupf","orcid":"0000-0001-7560-7657","position":4,"is_corresponding":false},{"id":27608,"name":"Richard Mayeux","orcid":"0000-0001-6519-9696","position":5,"is_corresponding":false},{"id":268543,"name":"Yian Gu","orcid":"0000-0002-4297-1548","position":6,"is_corresponding":false},{"id":661419,"name":"Jìng Guo","orcid":"0000-0002-2177-6970","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-18T23:44:13.017332Z","pmid":"33938146","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}