{"doi":"10.1002/alz.12318","title":"A novel tau‐based rhesus monkey model of Alzheimer's pathogenesis","abstract":"INTRODUCTION: Alzheimer's disease (AD) is a devastating condition with no effective treatments, with promising findings in rodents failing to translate into successful therapies for patients. METHODS: Targeting the vulnerable entorhinal cortex (ERC), rhesus monkeys received two injections of an adeno-associated virus expressing a double tau mutation (AAV-P301L/S320F) in the left hemisphere, and control AAV-green fluorescent protein in the right ERC. Noninjected aged-matched monkeys served as additional controls. RESULTS: Within 3 months we observed evidence of misfolded tau propagation, similar to what is hypothesized to occur in humans. Viral delivery of human 4R-tau also coaptates monkey 3R-tau via permissive templating. Tau spreading is accompanied by robust neuroinflammatory response driven by TREM2+ microglia, with biomarkers of inflammation and neuronal loss in the cerebrospinal fluid and plasma. DISCUSSION: These results highlight the initial stages of tau seeding and propagation in a primate model, a more powerful translational approach for the development of new therapies for AD.","journal":"Alzheimer s & Dementia","year":2021,"id":149867,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":100,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9346,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":232924,"name":"Paramita Chakrabarty","orcid":"0000-0002-6226-3776","position":1,"is_corresponding":false},{"id":636979,"name":"Sean Ott","orcid":"0000-0001-8792-7236","position":2,"is_corresponding":false},{"id":637673,"name":"Amanda Dao","orcid":null,"position":3,"is_corresponding":false},{"id":328272,"name":"Eric S. Zhou","orcid":"0000-0003-1038-8961","position":4,"is_corresponding":false},{"id":284300,"name":"William G.M. Janssen","orcid":"0000-0003-3954-7866","position":5,"is_corresponding":false},{"id":637674,"name":"Kristine Donis‐Cox","orcid":null,"position":6,"is_corresponding":false},{"id":637675,"name":"Scott Muller","orcid":null,"position":7,"is_corresponding":false},{"id":504782,"name":"Jeffrey H. Kordower","orcid":"0000-0001-8629-3294","position":8,"is_corresponding":false},{"id":515987,"name":"John H. Morrison","orcid":"0000-0002-8292-0964","position":9,"is_corresponding":false},{"id":636978,"name":"Danielle Beckman","orcid":"0000-0002-9584-4411","position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":null,"created_at":"2026-07-18T23:42:56.251607Z","pmid":"33734581","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}