{"doi":"10.1002/alz.12178","title":"The Brain Chart of Aging: Machine‐learning analytics reveals links between brain aging, white matter disease, amyloid burden, and cognition in the iSTAGING consortium of 10,216 harmonized MR scans","abstract":"INTRODUCTION: Relationships between brain atrophy patterns of typical aging and Alzheimer's disease (AD), white matter disease, cognition, and AD neuropathology were investigated via machine learning in a large harmonized magnetic resonance imaging database (11 studies; 10,216 subjects). METHODS: Three brain signatures were calculated: Brain-age, AD-like neurodegeneration, and white matter hyperintensities (WMHs). Brain Charts measured and displayed the relationships of these signatures to cognition and molecular biomarkers of AD. RESULTS: WMHs were associated with advanced brain aging, AD-like atrophy, poorer cognition, and AD neuropathology in mild cognitive impairment (MCI)/AD and cognitively normal (CN) subjects. High WMH volume was associated with brain aging and cognitive decline occurring in an ≈10-year period in CN subjects. WMHs were associated with doubling the likelihood of amyloid beta (Aβ) positivity after age 65. Brain aging, AD-like atrophy, and WMHs were better predictors of cognition than chronological age in MCI/AD. DISCUSSION: A Brain Chart quantifying brain-aging trajectories was established, enabling the systematic evaluation of individuals' brain-aging patterns relative to this large consortium.","journal":"Alzheimer s & Dementia","year":2020,"id":50738,"datarank":3.7535513512401066,"base_score":5.204006687076795,"endowment":5.204006687076795,"self_citation_contribution":0.7806010030615194,"citation_network_contribution":2.9729503481785873,"self_endowment_contribution":0.7806010030615194,"citer_contribution":2.9729503481785873,"corpus_percentile":94.01253190995591,"corpus_rank":775,"citation_count":181,"citer_count":100,"citers_with_citation_signal":88,"citers_with_endowment":88,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.9044,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":230033,"name":"Raymond Pomponio","orcid":"0000-0003-0434-4751","position":1,"is_corresponding":false},{"id":230046,"name":"Haochang Shou","orcid":"0000-0002-3043-047X","position":2,"is_corresponding":false},{"id":230028,"name":"Jimit Doshi","orcid":"0000-0002-2875-5814","position":3,"is_corresponding":false},{"id":250663,"name":"Elizabeth Mamourian","orcid":"0000-0001-8581-4887","position":4,"is_corresponding":false},{"id":34929,"name":"Guray Erus","orcid":"0000-0001-6633-4861","position":5,"is_corresponding":false},{"id":230030,"name":"Ilya M. Nasrallah","orcid":"0000-0003-2346-7562","position":6,"is_corresponding":false},{"id":17636,"name":"Lenore J. Launer","orcid":"0000-0002-3238-7612","position":7,"is_corresponding":false},{"id":252969,"name":"Tanweer Rashid","orcid":null,"position":8,"is_corresponding":false},{"id":250664,"name":"Murat Bilgel","orcid":"0000-0001-5042-7422","position":9,"is_corresponding":false},{"id":230034,"name":"Yong Fan","orcid":"0000-0001-9869-4685","position":10,"is_corresponding":false},{"id":244574,"name":"Jon B. Toledo","orcid":"0000-0003-4366-9268","position":11,"is_corresponding":false},{"id":55010,"name":"Kristine Yaffe","orcid":"0000-0003-0919-3825","position":12,"is_corresponding":false},{"id":236740,"name":"Aristeidis Sotiras","orcid":"0000-0003-0795-8820","position":13,"is_corresponding":false},{"id":230032,"name":"Dhivya Srinivasan","orcid":"0000-0001-7886-9572","position":14,"is_corresponding":false},{"id":226606,"name":"Mark A. Espeland","orcid":"0000-0002-3711-1949","position":15,"is_corresponding":false},{"id":230035,"name":"Colin L. Masters","orcid":"0000-0003-3072-7940","position":16,"is_corresponding":false},{"id":230036,"name":"Paul Maruff","orcid":"0000-0002-6947-9537","position":17,"is_corresponding":false},{"id":230039,"name":"Jürgen Fripp","orcid":"0000-0001-9705-0079","position":18,"is_corresponding":false},{"id":252970,"name":"Henry Völzk","orcid":null,"position":19,"is_corresponding":false},{"id":230038,"name":"Sterling C. Johnson","orcid":"0000-0002-8501-545X","position":20,"is_corresponding":false},{"id":27593,"name":"John C. Morris","orcid":"0000-0001-9820-5618","position":21,"is_corresponding":false},{"id":233950,"name":"Marilyn S. Albert","orcid":null,"position":22,"is_corresponding":false},{"id":87609,"name":"Michael I. Miller","orcid":"0000-0003-4689-3855","position":23,"is_corresponding":false},{"id":245385,"name":"R. Nick Bryan","orcid":"0000-0002-2327-4579","position":24,"is_corresponding":false},{"id":5329,"name":"Hans J. Grabe","orcid":"0000-0003-3684-4208","position":25,"is_corresponding":false},{"id":230044,"name":"Susan M. Resnick","orcid":"0000-0003-1115-7145","position":26,"is_corresponding":false},{"id":230045,"name":"David A. Wolk","orcid":"0000-0002-3554-3481","position":27,"is_corresponding":false},{"id":34918,"name":"Christos Davatzikos","orcid":"0000-0002-1025-8561","position":28,"is_corresponding":false},{"id":230029,"name":"Mohamad Habes","orcid":"0000-0001-9447-5805","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-18T20:39:29.006085Z","pmid":"32920988","pmcid":"PMC7923395","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}