{"doi":"10.1002/alz.12032","title":"Predicting sporadic Alzheimer's disease progression via inherited Alzheimer's disease‐informed machine‐learning","abstract":"INTRODUCTION: Developing cross-validated multi-biomarker models for the prediction of the rate of cognitive decline in Alzheimer's disease (AD) is a critical yet unmet clinical challenge. METHODS: We applied support vector regression to AD biomarkers derived from cerebrospinal fluid, structural magnetic resonance imaging (MRI), amyloid-PET and fluorodeoxyglucose positron-emission tomography (FDG-PET) to predict rates of cognitive decline. Prediction models were trained in autosomal-dominant Alzheimer's disease (ADAD, n = 121) and subsequently cross-validated in sporadic prodromal AD (n = 216). The sample size needed to detect treatment effects when using model-based risk enrichment was estimated. RESULTS: = 25%) in sporadic AD. Model-based risk-enrichment reduced the sample size required for detecting simulated intervention effects by 50%-75%. DISCUSSION: Our independently validated machine-learning model predicted cognitive decline in sporadic prodromal AD and may substantially reduce sample size needed in clinical trials in AD.","journal":"Alzheimer s & Dementia","year":2020,"id":57733,"datarank":0.6515708132780527,"base_score":4.343805421853684,"endowment":4.343805421853684,"self_citation_contribution":0.6515708132780527,"citation_network_contribution":0.0,"self_endowment_contribution":0.6515708132780527,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":76,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9482,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":98784,"name":"Nikolaos Koutsouleris","orcid":"0000-0001-6825-6262","position":1,"is_corresponding":false},{"id":301875,"name":"Tammie L.S. 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Gordon","orcid":"0000-0003-2109-2955","position":10,"is_corresponding":false},{"id":301878,"name":"Yen Ying Lim","orcid":"0000-0002-0308-5156","position":11,"is_corresponding":false},{"id":230035,"name":"Colin L. Masters","orcid":"0000-0003-3072-7940","position":12,"is_corresponding":false},{"id":49962,"name":"Martin N. Rossor","orcid":"0000-0001-8215-3120","position":13,"is_corresponding":false},{"id":66357,"name":"Nick C. Fox","orcid":"0000-0002-6660-657X","position":14,"is_corresponding":false},{"id":301879,"name":"Antoinette O’Connor","orcid":"0000-0003-4467-128X","position":15,"is_corresponding":false},{"id":301880,"name":"Jasmeer P. Chhatwal","orcid":"0000-0002-7792-1698","position":16,"is_corresponding":false},{"id":301881,"name":"Stephen Salloway","orcid":"0000-0002-2631-0942","position":17,"is_corresponding":false},{"id":301410,"name":"Adrian Danek","orcid":"0000-0001-8857-5383","position":18,"is_corresponding":false},{"id":226993,"name":"Jason Hassenstab","orcid":"0000-0002-7802-3371","position":19,"is_corresponding":false},{"id":245388,"name":"Peter R. Schofield","orcid":"0000-0003-2967-9662","position":20,"is_corresponding":false},{"id":27593,"name":"John C. Morris","orcid":"0000-0001-9820-5618","position":21,"is_corresponding":false},{"id":228359,"name":"Randall J. 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