{"doi":"10.1002/alr.70051","title":"The Impact of Chronic Particulate Matter Exposure on Quality‐of‐Life Outcomes After Endoscopic Sinus Surgery","abstract":"Chronic rhinosinusitis (CRS) is among the most common chronic upper airway diseases in the United States, with evidence suggesting chronic air pollutant exposure, such as fine particulate matter 2.5 (PM2.5), has implications in both its development and severity [1-4]. In the current study, we hypothesized that chronic PM2.5 exposure could adversely impact quality-of-life (QoL) outcomes after endoscopic sinus surgery (ESS) in CRS patients and sought to quantify this effect. Patients undergoing ESS were enrolled in a single-center prospective observational cohort study of CRS and followed for at least 6 months. Home addresses were converted into latitude and longitude coordinates for exposure estimation using the geocoder tool in DeGAUSS [5]. A validated open-source high-resolution spatiotemporal PM2.5 exposure model was used to estimate daily exposure and averaged to obtain an exposure summary measure in the year prior to surgery [6]. The 22-item Sino-Nasal Outcome Test (SNOT-22) was completed at baseline and subsequent follow-up appointments at 6, 12, 18, and 24 months to allow longitudinal evaluation of QoL outcomes. Survey results were also divided into the five underlying subdomains to allow analysis by symptom group (rhinologic, extra-nasal rhinologic, ear/facial symptoms, psychological, and sleep) [7]. Minimal clinically important differences (MCID) for each subdomain (3.8, 2.4, 3.2, 3.9, and 2.9 points, respectively) were used to evaluate for clinically meaningful changes in postoperative scores [8]. Multivariate linear regression models were used for the overall CRS cohort and the subpopulations of CRS with and without nasal polyps (CRSwNP, CRSsNP, respectively) to estimate the association between average preoperative 12-month PM2.5 exposures and postoperative QoL outcomes after adjusting for sociodemographic variables known to be associated with PM2.5 exposure, including RUCA scores and income. All analyses were conducted in R version 4.2.1 (R Core Team, Vienna, Austria) on the Vanderbilt Advanced Computing Cluster for Research and Education (ACCRE). A prespecified alpha threshold of 0.05 was used to determine statistical significance. A total of 226 CRS patients met inclusion criteria and had sufficient follow-up of at least 6 months, with 113 patients in both subpopulations of CRSwNP and CRSsNP (Table S1). Mean 12-month PM2.5 levels for the group were estimated at 8.2 µg/m3, with a range of 6.5–13 µg/m3. The mean (SD) baseline total SNOT-22 score for the overall CRS cohort was 43.7 (19.9), indicative of a moderately severe level of QoL impairment. The mean overall postoperative change in SNOT-22 scores in our patient population was −21.4 ± 21.5 points, demonstrating a notable QoL improvement after ESS. The most common follow-up length was 6 months (31%), with decreasing frequency over subsequent time intervals with 19% of the overall population having a follow-up length of 24 months. Results from multivariate regression modeling of SNOT-22 total and subdomain change scores after ESS in relation to mean 12-month PM2.5 levels are shown in Tables 1 and 2 for CRSwNP and CRSsNP, respectively. In CRSwNP, a significant association between PM2.5 exposure and the magnitude of postoperative improvement was identified (β = 8.25, p = 0.036), with higher exposure associated with less improvement in total SNOT-22 scores. By subgroup, there were significant similar associations in the overall change in the psychological domain score (β = 3.68, p = 0.013) and overall sleep domain score (β = 2.57, p = 0.037). Notably, no statistically significant associations were observed between postoperative SNOT-22 total or subdomain scores and 12-month PM2.5 exposures in CRSsNP subgroup. The results of this study suggest that chronic PM2.5 exposure is a potential risk factor for reduced QoL improvement after ESS in CRSwNP patients. The results of our multivariate regression identified that for each 1 µg/m3 increase in 12-month PM2.5 exposure, th","journal":"International Forum of Allergy & Rhinology","year":2025,"id":547830,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9581,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1440603,"name":"Nanda Nayak","orcid":"0009-0000-9986-5845","position":1,"is_corresponding":false},{"id":1250005,"name":"Christina Dorismond","orcid":"0000-0002-4333-9763","position":2,"is_corresponding":false},{"id":1044126,"name":"Rory J. Lubner","orcid":"0000-0001-9884-2799","position":3,"is_corresponding":false},{"id":1440604,"name":"Daniel H. Lofgren","orcid":"0000-0003-3027-3694","position":4,"is_corresponding":false},{"id":268691,"name":"Ping Li","orcid":"0000-0002-4549-9517","position":5,"is_corresponding":false},{"id":263307,"name":"Katherine N. Cahill","orcid":"0000-0002-8549-1835","position":6,"is_corresponding":false},{"id":1250006,"name":"Mason R. Krysinski","orcid":"0000-0002-6156-0349","position":7,"is_corresponding":false},{"id":343812,"name":"Rakesh K. Chandra","orcid":"0000-0002-3612-0026","position":8,"is_corresponding":false},{"id":343814,"name":"Justin H. Turner","orcid":"0000-0002-5501-9900","position":9,"is_corresponding":false},{"id":343813,"name":"Naweed I. Chowdhury","orcid":"0000-0001-9826-4917","position":10,"is_corresponding":false},{"id":1440602,"name":"Chandler J. Rygalski","orcid":"0000-0001-7197-1822","position":0,"is_corresponding":true}],"reference_count":10,"raw_metadata":null,"created_at":"2026-07-19T02:53:53.962932Z","pmid":"41117365","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}