{"doi":"10.1002/alr.23550","title":"Deletion of Nrf2 Enhances Susceptibility to Sinonasal Inflammation After Short‐Term PM<sub>2.5</sub> Exposure","abstract":"ABSTRACT Background Particulate matter 2.5 (PM 2.5 ) has been identified as one of the most pathogenic components of air pollution and has been associated with chronic rhinosinusitis (CRS) prevalence and severity. Nuclear erythroid 2‐related factor 2 (Nrf2), an antioxidant transcription factor, is critical for protective responses against environmental exposures, such as PM 2.5 . The goal of this study was to elucidate the role of Nrf2 in a short‐term PM 2.5 ‐induced murine model of CRS. Methods C57BL/6 wild‐type ( n = 12) and Nrf2‐deficient ( n = 12) mice were intranasally challenged with 400 µg of PM 2.5 or saline alone for 2 weeks. Heads were harvested and sectioned to perform IHC and flow cytometry, and sinonasal mucosa was dissected to perform qPCR. Results Nrf2 −/− mice exhibited a 50% increase in sinonasal inflammation, with a neutrophilic predominance. Nrf2 deficiency also promoted elevated levels of sinonasal Muc5ac expression and increased expression of type 2, type 3, and epithelial‐derived cytokines. Conclusion This study demonstrates that the Nrf2 antioxidant pathway is critical in controlling short‐term PM 2.5 ‐induced sinonasal type 3 inflammation and may represent a potential therapeutic target to modulate the inflammatory response induced by air pollution. This is the first study to our knowledge to demonstrate that Nrf2 regulates PM 2.5 ‐induced rhinosinusitis in vivo.","journal":"International Forum of Allergy & Rhinology","year":2025,"id":525316,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9656,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1211632,"name":"Asiana Gurung","orcid":null,"position":1,"is_corresponding":false},{"id":610842,"name":"Nyall R. London","orcid":"0000-0002-2902-4407","position":2,"is_corresponding":false},{"id":1400479,"name":"Stefany Lazieh","orcid":null,"position":3,"is_corresponding":false},{"id":74315,"name":"Shyam Biswal","orcid":"0000-0003-0431-3939","position":4,"is_corresponding":false},{"id":240457,"name":"Murugappan Ramanathan","orcid":"0000-0002-7612-9586","position":5,"is_corresponding":false},{"id":276479,"name":"Anuj Tharakan","orcid":null,"position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-19T02:50:21.274116Z","pmid":"40013898","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}