{"doi":"10.1002/alr.23320","title":"Cognition and saccadic eye movement performance are impaired in chronic rhinosinusitis","abstract":"BACKGROUND: Patients with chronic rhinosinusitis (CRS) can experience cognitive dysfunction. The literature on this topic mostly reflects patient-reported measurements. Our goal was to assess cognitive function in patients with CRS using objective measures, including saccadic eye movements-a behavioral response reflecting cognitive and sensory information integration that is often compromised in conditions with impaired cognition. METHODS: Participants (N = 24 with CRS, N = 23 non-CRS healthy controls) enrolled from rhinology clinic underwent sinonasal evaluation, quality of life assessment (Sino-nasal Outcome Test 22 [SNOT-22]), and cognitive assessment with the Neuro-QOL Cognitive Function-Short Form, the Montreal Cognitive Assessment (MoCA), and recording of eye movements using video-oculography. RESULTS: Participants with CRS were more likely to report cognitive dysfunction (Neuro-QOL; 45.8% vs. 8.7%; p = 0.005) and demonstrate mild or greater cognitive impairment (MoCA; 41.7% vs. 8.7%; p = 0.005) than controls. Additionally, participants with CRS performed worse on the MoCA overall and within the executive functioning and memory domains (all p < 0.05) and on the anti-saccade (p = 0.014) and delay saccade (p = 0.044) eye movement tasks. Poorer performance on the MoCA (r = -0.422; p = 0.003) and the anti-saccade (r = -0.347; p = 0.017) and delay saccade (r = -0.419; p = 0.004) eye movement tasks correlated with worse CRS severity according to SNOT-22 scores. CONCLUSION: This study is the first to utilize objective eye movement assessments in addition to researcher-administered cognitive testing in patients with CRS. These patients demonstrated a high prevalence of cognitive dysfunction, most notably within executive functioning and memory domains, with the degree of dysfunction correlating with the severity of CRS.","journal":"International Forum of Allergy & Rhinology","year":2024,"id":464673,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9638,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1295927,"name":"Heather Wood","orcid":null,"position":1,"is_corresponding":false},{"id":1295606,"name":"Mohamed Aboueisha","orcid":"0000-0003-2747-5009","position":2,"is_corresponding":false},{"id":1295928,"name":"Thomas B. Marshall","orcid":null,"position":3,"is_corresponding":false},{"id":442488,"name":"Tzu‐Cheg Kao","orcid":null,"position":4,"is_corresponding":false},{"id":370181,"name":"James O. Phillips","orcid":null,"position":5,"is_corresponding":false},{"id":1295607,"name":"Ian M. Humphreys","orcid":"0000-0002-6832-754X","position":6,"is_corresponding":false},{"id":834486,"name":"Waleed M. Abuzeid","orcid":"0000-0003-2489-0514","position":7,"is_corresponding":false},{"id":521162,"name":"Ashton E. Lehmann","orcid":"0000-0002-0489-0181","position":8,"is_corresponding":false},{"id":623727,"name":"Yoshiko Kojima","orcid":"0000-0003-0777-3308","position":9,"is_corresponding":false},{"id":449719,"name":"Aria Jafari","orcid":"0000-0002-5254-3221","position":10,"is_corresponding":false},{"id":1295605,"name":"David J. Cvancara","orcid":"0009-0009-9685-5575","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:04:42.082401Z","pmid":"38268115","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}