{"doi":"10.1002/alr.23130","title":"Management paradigms for chronic rhinosinusitis in individuals with asthma: An evidence‐based review with recommendations","abstract":"BACKGROUND: Despite the significant morbidity associated with chronic rhinosinusitis (CRS) in individuals with asthma (CRSwA), there is a paucity of codified, evidence-based management strategies for CRS in this population. METHODS: Using PubMed, Embase, and Cochrane Review Databases, a systematic review was performed covering management strategies for CRSwA. A total of 5903 articles were screened, and 70 were included for full-text analysis. After application of exclusion criteria, 53 articles comprised the qualitative synthesis. The level of evidence was graded and benefit-harm assessments, as well as value judgment and recommendations, were provided RESULTS: Strong evidence confirms the benefit of oral and topical medications on sinonasal-specific outcomes in individuals with CRSwA; there is low-grade evidence demonstrating that these agents improve lung function and/or asthma control. Moderate to strong evidence suggests that endoscopic sinus surgery (ESS) improves both sinonasal- and asthma-specific quality of life. Although there is insufficient to low evidence to indicate that ESS improves pulmonary function in this population, data indicate a positive impact of this intervention on asthma control. Biologic medications strongly improve both subjective and objective sinonasal- and asthma-specific outcomes. CONCLUSION: Evidence supports managing CRS in individuals with CRSwA in a stepwise fashion, starting with traditional nonbiologic oral and topical medication, and escalating to second-line treatments, such as ESS and biologics. Optimal treatment of individuals who have CRSwA often requires concurrent, directed management of asthma, as not all CRS interventions impact asthma status.","journal":"International Forum of Allergy & Rhinology","year":2022,"id":269852,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6297,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":417728,"name":"Jeremiah A. Alt","orcid":"0000-0003-0560-5028","position":1,"is_corresponding":false},{"id":75233,"name":"Kara Y. Detwiller","orcid":null,"position":2,"is_corresponding":false},{"id":240455,"name":"Nicholas R. Rowan","orcid":"0000-0003-1296-2648","position":3,"is_corresponding":false},{"id":386858,"name":"Stacey T. Gray","orcid":null,"position":4,"is_corresponding":false},{"id":498145,"name":"Peter W. Hellings","orcid":"0000-0001-6898-688X","position":5,"is_corresponding":false},{"id":386198,"name":"Shyam Joshi","orcid":"0000-0002-1867-0649","position":6,"is_corresponding":false},{"id":933098,"name":"Jivianne T. Lee","orcid":"0000-0002-0711-855X","position":7,"is_corresponding":false},{"id":933491,"name":"Zach M. Soler","orcid":null,"position":8,"is_corresponding":false},{"id":348700,"name":"Bruce K. Tan","orcid":"0000-0001-9210-5050","position":9,"is_corresponding":false},{"id":486163,"name":"Jennifer L. Taylor‐Cousar","orcid":"0000-0002-5436-9722","position":10,"is_corresponding":false},{"id":660746,"name":"Sarah K. Wise","orcid":"0000-0002-6398-0056","position":11,"is_corresponding":false},{"id":933099,"name":"Tara J. Wu","orcid":"0000-0002-6493-5927","position":12,"is_corresponding":false},{"id":417729,"name":"Daniel M. Beswick","orcid":"0000-0001-8612-5442","position":13,"is_corresponding":false},{"id":749486,"name":"Amarbir S. Gill","orcid":"0000-0002-6776-0712","position":0,"is_corresponding":true}],"reference_count":125,"raw_metadata":null,"created_at":"2026-07-19T00:27:22.602796Z","pmid":"36579899","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}