{"doi":"10.1002/alr.23002","title":"CRS‐PRO and SNOT‐22 correlations with type 2 inflammatory mediators in chronic rhinosinusitis","abstract":"The 22-item Sino-Nasal Outcome Test (SNOT-22) and 12-item Patient Reported Outcomes in Chronic Rhinosinusitis (CRS-PRO) instrument are validated patient-reported outcomes measures in CRS. In this study we assess the correlation of these with type 2 (T2) biomarkers before and after endoscopic sinus surgery (ESS). METHODS: Middle meatal mucus data were collected and the SNOT-22 and CRS-PRO were administered to 123 patients (71 CRS without nasal polyps [CRSsNP], 52 CRS with nasal polyps [CRSwNP]) with CRS before and 6 to 12 months after undergoing ESS. Interleukin (IL)-4, IL-5, IL-13, and eosinophilic cationic protein (ECP) were measured using a multiplexed bead assay and enzyme-linked immunoassay. Pre- and post-ESS SNOT-22 and CRS-PRO were compared with T2 biomarkers. RESULTS: Before ESS neither PROM correlated with any biomarker. After ESS, CRS-PRO showed a correlation with 2 mediators (IL-5 and IL-13: p = 0.012 and 0.003, respectively) compared with none for the SNOT-22. For CRSwNP patients, pre-ESS CRS-PRO and SNOT-22 correlated with IL-4 (p = 0.04 for both). However, after ESS, CRS-PRO correlated with 3 biomarkers (IL-5, IL-13, and ECP: p = 0.02, 0.024, and 0.04, respectively) and SNOT-22 with 2 biomarkers (IL-5 and IL-13: p = 0.038 and 0.02, respectively). There were no significant relationships between any of the T2 biomarkers pre- or post-ESS among patients with CRSsNP. Exploratory analyses of the subdomains showed the SNOT-22 rhinologic and CRS-PRO rhinopsychologic subdomains correlated better with the T2 biomarkers. On individual item analysis, IL-13 correlated significantly post-ESS with 8 of 12 items on the CRS-PRO vs 6 of 22 items on the SNOT-22. CONCLUSION: The CRS-PRO total score showed a significant correlation with T2 biomarkers especially when assessed post-ESS and among CRSwNP patients.","journal":"International Forum of Allergy & Rhinology","year":2022,"id":251022,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9183,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":246819,"name":"Alexander L. Schneider","orcid":"0000-0001-9013-646X","position":1,"is_corresponding":false},{"id":830306,"name":"Meera Ganesh","orcid":"0000-0002-3983-215X","position":2,"is_corresponding":false},{"id":710969,"name":"Julia Huang","orcid":null,"position":3,"is_corresponding":false},{"id":893812,"name":"David Lehmann","orcid":"0000-0002-8735-2847","position":4,"is_corresponding":false},{"id":246814,"name":"Caroline P.E. Price","orcid":"0000-0002-9590-7419","position":5,"is_corresponding":false},{"id":894466,"name":"Samuel G. Rodegherio","orcid":null,"position":6,"is_corresponding":false},{"id":893813,"name":"Abhita Reddy","orcid":"0000-0002-7617-861X","position":7,"is_corresponding":false},{"id":893814,"name":"Jacob G. Eide","orcid":"0000-0003-3727-8287","position":8,"is_corresponding":false},{"id":480724,"name":"David B. Conley","orcid":"0000-0002-2611-6795","position":9,"is_corresponding":false},{"id":480725,"name":"Kevin C. Welch","orcid":"0000-0003-4863-7206","position":10,"is_corresponding":false},{"id":386199,"name":"Robert C. Kern","orcid":"0000-0002-8995-9175","position":11,"is_corresponding":false},{"id":520504,"name":"Stephanie S. Smith","orcid":"0000-0002-0605-3993","position":12,"is_corresponding":false},{"id":262060,"name":"Atsushi Kato","orcid":"0000-0001-9144-3138","position":13,"is_corresponding":false},{"id":233264,"name":"Robert P. Schleimer","orcid":"0000-0002-8330-0097","position":14,"is_corresponding":false},{"id":348700,"name":"Bruce K. Tan","orcid":"0000-0001-9210-5050","position":15,"is_corresponding":false},{"id":246818,"name":"Samuel D. Racette","orcid":"0000-0001-6731-2744","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-19T00:24:37.429628Z","pmid":"35363947","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}