{"doi":"10.1002/ajoc.202500121","title":"Production Of <sup>11</sup> C‐Labeled Amides Via “In‐Loop” <sup>11</sup> C‐Carbonylation","abstract":"Abstract The carbon‐11 ( 11 C) labeling of benzamides holds great promise in the development of PET radiotracers given the prevalence of benzamides in bioactive molecules. This work establishes an improved automated route to 11 C labeled primary benzamides through carbonylative cross‐coupling of aryl halides with 11 C carbon monoxide using electrophilic aroyl dimethylaminopyridinium salts as an intermediate. The methodology uses GE TRACERLab FX automated radiochemistry synthesis modules and allows for the synthesis of a variety of benzamide containing compounds, including known PET imaging agent [ 11 C]LY2795050, a KOR antagonist, in moderate to excellent radiochemical yields. This not only provides a practical means of synthesizing primary [ 11 C]benzamides, but it sets the stage for potential future applications in PET tracer synthesis. Overall, this development offers a versatile tool for generating 11 C‐labeled compounds for PET imaging applications thus, opening new avenues in the field of molecular imaging and advancing our understanding of various biological processes.","journal":"Asian Journal of Organic Chemistry","year":2025,"id":543538,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9514,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1045483,"name":"Xia Shao","orcid":"0000-0002-7291-2477","position":1,"is_corresponding":false},{"id":350841,"name":"Allen F. Brooks","orcid":"0000-0003-3773-3024","position":2,"is_corresponding":false},{"id":342700,"name":"Peter J. H. Scott","orcid":"0000-0002-6505-0450","position":3,"is_corresponding":false},{"id":754719,"name":"Tanpreet Kaur","orcid":"0000-0002-4700-3116","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-19T02:53:04.088079Z","pmid":"40857482","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}