{"doi":"10.1002/ajmg.b.32805","title":"Genome‐wide admixture mapping of<scp>DSM‐IV</scp>alcohol dependence, criterion count, and the self‐rating of the effects of ethanol in African American populations","abstract":"African Americans (AA) have lower prevalence of alcohol dependence and higher subjective response to alcohol than European Americans. Genome-wide association studies (GWAS) have identified genes/variants associated with alcohol dependence specifically in AA; however, the sample sizes are still not large enough to detect variants with small effects. Admixture mapping is an alternative way to identify alcohol dependence genes/variants that may be unique to AA. In this study, we performed the first admixture mapping of DSM-IV alcohol dependence diagnosis, DSM-IV alcohol dependence criterion count, and two scores from the self-rating of effects of ethanol (SRE) as measures of response to alcohol: the first five times of using alcohol (SRE-5) and average of SRE across three times (SRE-T). Findings revealed a region on chromosome 4 that was genome-wide significant for SRE-5 (p value = 4.18E-05). Fine mapping did not identify a single causal variant to be associated with SRE-5; instead, conditional analysis concluded that multiple variants collectively explained the admixture mapping signal. PPARGC1A, a gene that has been linked to alcohol consumption in previous studies, is located in this region. Our finding suggests that admixture mapping is a useful tool to identify genes/variants that may have been missed by current GWAS approaches in admixed populations.","journal":"American Journal of Medical Genetics Part B Neuropsychiatric Genetics","year":2020,"id":86562,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9366,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":27578,"name":"Manav Kapoor","orcid":"0000-0001-6682-940X","position":1,"is_corresponding":false},{"id":230718,"name":"Leah Wetherill","orcid":"0000-0003-2888-9051","position":2,"is_corresponding":false},{"id":345453,"name":"Melanie L. Schwandt","orcid":"0000-0002-8355-4900","position":3,"is_corresponding":false},{"id":395967,"name":"Vijay A. Ramchandani","orcid":"0000-0003-2474-2183","position":4,"is_corresponding":false},{"id":315143,"name":"David Goldman","orcid":"0000-0002-1724-5405","position":5,"is_corresponding":false},{"id":303420,"name":"Michael J. Chao","orcid":null,"position":6,"is_corresponding":false},{"id":24671,"name":"Laura Almasy","orcid":"0000-0002-9184-8124","position":7,"is_corresponding":false},{"id":230701,"name":"Kathleen K. Bucholz","orcid":"0000-0003-3794-0736","position":8,"is_corresponding":false},{"id":79326,"name":"Ronald P. Hart","orcid":"0000-0003-4836-8712","position":9,"is_corresponding":false},{"id":321824,"name":"Chella Kamarajan","orcid":null,"position":10,"is_corresponding":false},{"id":230711,"name":"Jacquelyn L. Meyers","orcid":"0000-0003-3863-8555","position":11,"is_corresponding":false},{"id":40253,"name":"John I. Nürnberger","orcid":"0000-0002-7674-1767","position":12,"is_corresponding":false},{"id":247080,"name":"Jay A. Tischfield","orcid":"0000-0003-3217-8287","position":13,"is_corresponding":false},{"id":230003,"name":"Howard J. Edenberg","orcid":"0000-0003-0344-9690","position":14,"is_corresponding":false},{"id":320086,"name":"Marc A. Schuckit","orcid":"0000-0002-2323-7858","position":15,"is_corresponding":false},{"id":27629,"name":"Alison Goate","orcid":"0000-0002-0576-2472","position":16,"is_corresponding":false},{"id":441520,"name":"Denise M. Scott","orcid":"0000-0002-3676-6572","position":17,"is_corresponding":false},{"id":230728,"name":"Bernice Porjesz","orcid":"0000-0003-2489-0389","position":18,"is_corresponding":false},{"id":230004,"name":"Arpana Agrawal","orcid":"0000-0002-0313-793X","position":19,"is_corresponding":false},{"id":40730,"name":"Tatiana Foroud","orcid":"0000-0002-5549-2212","position":20,"is_corresponding":false},{"id":94634,"name":"Dongbing Lai","orcid":"0000-0001-7803-580X","position":0,"is_corresponding":true}],"reference_count":76,"raw_metadata":null,"created_at":"2026-07-18T21:59:03.706190Z","pmid":"32652861","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}